Ocular pathology in the oculo-cerebro-renal syndrome of Lowe.
Ocular pathology in the oculo-cerebro-renal syndrome of Lowe.
复制标题
Lowe 眼脑肾综合征的眼部病理学。
DOI：
10.1016/0002-9394(67)90556-9
复制
发表时间：
1967
影响因子：
4.2
通讯作者：
N. Ballin
中科院分区：
文献类型：
--
作者：
V. Curtin;E. E. Joyce;N. Ballin
1952年，Lowe描述了三个智力和身体发育迟缓的病例，包括反射减退、肌张力下降、佝偻病、白内障和青光眼。在过去的几年里，这种综合征越来越多地被认识到。1959年，弗朗; ois 2回顾了12例病例的眼部表现; 1963年，Wilson 3在文献报道的23例病例中增加了8例; Chutorian 4在1966年回顾了46例; Haut 6在最近的回顾中汇编了55例。只有三例死亡前诊断的病例和一例尸检结果怀疑的病例报告了眼睛的病理学研究。这种疾病的眼部病理学可能是如此特异，以至于可以单独在此基础上做出诊断。在两个惊人相似的案例中对这些发现的证明为本文提供了动力。病例1最初是在1963年于华盛顿举行的Verhoeff学会会议上由Lorenz E.齐默尔曼。后来，它被用来说明齐默尔曼和丰特关于“眼睛先天畸形”的论文。g本病例记录了临床病史，并揭示了本病例的组织病理学变化与巴斯科姆帕尔默眼科研究所研究的病例（病例2）的相似性。
In 1952, Lowe’described three cases of mental and physical retardation with hyporeflexia, decreased muscle tone, rickets, cataracts and glaucoma. This syndrome has been recognized with increasing frequency in the past few years. In 1959, Franr; ois2 reviewed the ocular findings in 12 cases; in 1963, Wilson3 added eight cases to 23 reported in the literature; Chutorian4 reviewed 46 cases in 1966; and Haut6 compiled 55 cases in the most recent review. Pathologic study of the eyes has been reported only in three cases6’g diagnosed prior to death and in one caselo suspected by the general autopsy findings. The ocular pathology in this disease may be so specific that the diagnosis can be made on this basis alone. The demonstration of these findings in two strikingly similar cases provided the stimulus for this paper. Case 1 was originally presented at the 1963 meeting of the Verhoeff Society in Washington, DC, by Dr. Lorenz E. Zimmerman. It was subsequently used to illustrate the paper on “Congenital malformations of the eye” by Zimmerman and Font. g This case is presented here to record the clinical history and to reveal how dramatically similar are the histopathologic changes in this case campared with one studied at the Bascom Palmer Eye Institute (Case 2).