PROTEIN-RESISTANT SURFACES PREPARED BY PEO-CONTAINING BLOCK COPOLYMER SURFACTANTS
PROTEIN-RESISTANT SURFACES PREPARED BY PEO-CONTAINING BLOCK COPOLYMER SURFACTANTS
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DOI：
10.1002/jbm.820230306
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发表时间：
1989-03-01
期刊：
影响因子：
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通讯作者：
ANDRADE, JD
中科院分区：
文献类型：
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作者：
LEE, JH;KOPECEK, J;ANDRADE, JD
研究了含有聚氧化乙烯(PEO)的非离子聚合物表面活性剂，作为一种可能的方法，通过对常见的疏水医用材料SBD.聚乙烯进行简单的涂层处理来制备富含PEO的表面。用Wilhelmy平板表面张力技术和X射线光电子能谱(XPS)研究了PEO/聚环氧丙烷(PPO)和PEO/聚丁二烯(PBO)嵌段共聚表面活性剂在疏水表面(低密度聚乙烯，LDPE)上的表面张力和吸附性能。用XPS和~(125)I标记的蛋白质对表面活性剂处理后的表面蛋白质的抗性进行了评价。数据表明，表面活性剂在LDPE上的吸附取决于表面活性剂的分子几何构型。与未处理的表面相比，表面活性剂处理的LDPE表面对人血清白蛋白的吸附显著降低。讨论了适合于制备富含PEO表面的表面活性剂以及它们抵抗蛋白质的可能机制。
Polyethylene oxide(PEO)-containing nonionic polymeric surfactants were studied as a possible means to produce PEO-rich surfaces by a simple coating treatment of a common hydrophobic medical material .sbd.polyethylene. Surface tension and adsorption properties of PEO/polypropylene oxide (PPO) and PEO/polybutylene oxide(PBO) block copolymer surfactants on a hydrophobic surface (low density polyethylene, LDPE) were investigated, using the Wilhelmy plate surface tension technique and x-ray photoelectron spectroscopy(XPS). The protein resistance of the surfactant-treated surfaces was evaluated by XPS and 125I-labeled proteins. The data presented indicate that adsorption of the surfactants on LDPE is dependent on the molecular geometry of the surfactants. Adsorption of human albumin was significantly decreased on the surfactant-treated LDPE surfaces, as compared with the untreated surface. Surfactants suitable for the preparation of PEO-rich surfaces and possible mechanisms for their protein resistance are discussed.