Calcium Signaling in Cardiomyocyte Function
Calcium Signaling in Cardiomyocyte Function
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DOI：
10.1101/cshperspect.a035428
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发表时间：
2020-03-01
影响因子：
7.2
通讯作者：
Roderick, H. Llewelyn
中科院分区：
文献类型：
--
作者：
Gilbert, Guillaume;Demydenko, Kateryna;Roderick, H. Llewelyn
细胞内 Ca2+ 浓度的节律性增加是心脏收缩功能的基础。这些心肌细胞内 Ca2+ 的变化是由动作电位对心肌细胞肌膜的电去极化诱导和协调的。该电信号起源于窦房结，在整个心脏中传导，确保单个肌细胞同步进入有效的心脏泵。 Ca2+ 信号通路还调节发育和病理过程中的基因表达和心肌细胞生长。心血管疾病中 Ca2+ 稳态改变的普遍性说明了 Ca2+ 在心脏中的这些基本作用。事实上，心力衰竭（心脏无法支持血流动力学需求）、节律紊乱和心脏生长不当都与 Ca2+ 处理方式的改变有关。这些病理学的流行导致了发达国家三分之一的死亡以及大量的发病率，因此了解心肌细胞中 Ca(2+) 处理和失调的机制非常重要。
Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and coordinated by electrical depolarization of the cardiomyocyte sarcolemma by the action potential. Originating at the sinoatrial node, conduction of this electrical signal throughout the heart ensures synchronization of individual myocytes into an effective cardiac pump. Ca2+ signaling pathways also regulate gene expression and cardiomyocyte growth during development and in pathology. These fundamental roles of Ca2+ in the heart are illustrated by the prevalence of altered Ca2+ homeostasis in cardiovascular diseases. Indeed, heart failure (an inability of the heart to support hemodynamic needs), rhythmic disturbances, and inappropriate cardiac growth all share an involvement of altered Ca2+ handling. The prevalence of these pathologies, contributing to a third of all deaths in the developed world as well as to substantial morbidity makes understanding the mechanisms of Ca(2+ )handling and dysregulation in cardiomyocytes of great importance.