Foveal Anatomic Associations with the Secondary Peak and the Slope of the Macular Pigment Spatial Profile
Foveal Anatomic Associations with the Secondary Peak and the Slope of the Macular Pigment Spatial Profile
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DOI：
10.1167/iovs.08-2494
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发表时间：
2009-03-01
影响因子：
4.4
通讯作者：
Nolan, John M.
中科院分区：
文献类型：
--
作者：
Kirby, Mark L.;Galea, Martin;Nolan, John M.
目的.探讨异色闪烁光度法（HFP）测量黄斑色素（MP）空间分布的可重复性，并将MP空间分布与黄斑中心凹结构相关联。招募了16名健康受试者（9名具有典型的指数MP空间分布[第1组]; 7名具有次峰MP空间分布[第2组]）。在三个不同的场合测量MP空间分布。在每个轨迹处获得六个辐射率测量值（0.25、0.5度、1度和1.75度偏心率;参考点，7度）。通过光学相干断层扫描（OCT）评估中心凹结构。具有典型下降特征的受试者在平均重复测量后具有该特征（组1）。出现次峰的受试者在重复测量后平均显示次峰（第2组）。第1组的平均SD中心凹宽度明显窄于第2组的平均SD中心凹宽度（分别为1306 ± 240 μ m和1915 ± 161 μ m; P <0.01）。调整性别后，这种差异仍然存在（P <0.001）。经性别校正后，中心凹宽度与平均中心凹MP显著相关（r = 0.588，P = 0.021）。去除异常值后，黄斑中心凹轮廓斜率与MP空间轮廓斜率显著相关（r = 0.591，P = 0.020）。HFP可重复测量MP空间分布。在MP空间分布中看到的次级峰不能归因于测量误差，并且与更宽的中央凹相关。个体的MP空间轮廓的斜率与中央凹斜率相关，更陡的MP分布与更陡的中央凹凹陷相关。（Invest Ophthalmol维斯科学。2009; 50：1383 - 1391）DOI：10.1167/iovs.08 - 2494
PURPOSE. To investigate the reproducibility of the macular pigment (MP) spatial profile by using heterochromatic flicker photometry (HFP) and to relate the MP spatial profile to foveal architecture.METHODS. Sixteen healthy subjects (nine had the typical exponential MP spatial profile [group 1]; seven had a secondary peak MP spatial profile [group 2]) were recruited. The MP spatial profile was measured on three separate occasions. Six radiance measurements were obtained at each locus (0.25, 0.5 degrees, 1 degrees, and 1.75 degrees eccentricity; reference point, 7 degrees). Foveal architecture was assessed by optical coherence tomography (OCT).RESULTS. Subjects who had the typical decline profile, had this profile after averaging repeated measures (group 1). Subjects who had a secondary peak, displayed the secondary peak after repeated measures were averaged (group 2). Mean SD foveal width in group 1 was significantly narrower than mean SD foveal width in group 2 (1306 =/- 240 mu m and 1915 +/- 161 mu m, respectively; P < 0.01). This difference remained after adjustment for sex (P < 0.001). Foveal width was significantly related to mean foveal MP, with adjustment for sex (r = 0.588, P = 0.021). Foveal profile slope was significantly related to MP spatial profile slope, after removal of an outlier (r = 0.591, P = 0.020).CONCLUSIONS. HFP reproducibly measures MP spatial profile. Secondary peaks seen in the MP spatial profile cannot be attributed to measurement error and are associated with wider foveas. The slope of an individual's MP spatial profile is related to foveal slope, with a steeper MP distribution associated with a steeper foveal depression. (Invest Ophthalmol Vis Sci. 2009; 50: 1383-1391) DOI: 10.1167/iovs.08-2494