Dioxin emissions from a solid waste incinerator and risk of non-Hodgkin lymphoma
Dioxin emissions from a solid waste incinerator and risk of non-Hodgkin lymphoma
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DOI：
10.1097/01.ede.0000072107.90304.01
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发表时间：
2003-07-01
期刊：
影响因子：
5.4
通讯作者：
Viel, JF
中科院分区：
文献类型：
--
作者：
Floret, N;Mauny, F;Viel, JF
背景：目前尚不清楚低环境剂量的二恶英是否会影响普通人群。我们之前在法国一座二恶英排放量较高的城市固体废物焚烧炉周围发现了一群非霍奇金淋巴瘤患者。为了探索这些发现所暗示的环境途径，我们在同一地区进行了一项基于人群的病例对照研究。方法：我们使用 10 比 1 匹配的方法，比较了 1980 年至 1995 年间诊断的 222 例非霍奇金淋巴瘤病例和从 1990 年人口普查中随机选择的对照。二恶英地面浓度采用第二代高斯型分散模型进行建模，得出四种二恶英暴露类别。后者利用地理信息系统技术与个人居住地联系起来。 结果：居住在二恶英浓度最高地区的个人患非霍奇金淋巴瘤的风险比居住在二恶英浓度最低地区的个人高 2.3 倍（95% 置信区间 = 1.4-3.8）。未发现中等二恶英暴露类别的风险增加。在街区组水平上对广泛的社会经济特征进行调整并没有改变结果。结论：尽管与其他背景来源相比，焚烧炉的排放通常不被视为二恶英暴露的重要来源，但我们的研究结果支持这样的假设：环境二恶英会增加生活在城市固体废物焚烧炉附近的人口患非霍奇金淋巴瘤的风险。
Background: It is not clear whether low environmental doses of dioxin affect the general population. We previously detected a cluster of patients with non-Hodgkin lymphoma around a French municipal solid waste incinerator with high dioxin emissions. To explore the environmental route suggested by these findings, we carried out a population-based case-control study in the same area.Methods: We compared 222 incident cases of non-Hodgkin lymphoma diagnosed between 1980 and 1995 and controls randomly selected from the 1990 population census, using a 10-to-1 match. Dioxin ground-level concentrations were modeled with a second-generation Gaussian-type dispersion model, yielding four dioxin exposure categories. The latter were linked to individual places of residence, using Geographic Information System technology.Results: The risk of developing non-Hodgkin lymphoma was 2.3 times higher (95% confidence interval = 1.4-3.8) among individuals living in the area with the highest dioxin concentration than among those living in the area with the lowest dioxin concentration. No increased risk was found for the intermediate dioxin exposure categories. Adjustment for a wide range of socioeconomic characteristics at the block group level did not alter the results.Conclusion: Although emissions from incinerators are usually not regarded as an important source of exposure to dioxins compared with other background sources, our findings support the hypothesis that environmental dioxins increase the risk of non-Hodgkin lymphoma among the population living in the vicinity of a municipal solid waste incinerator.