COULD HLA-DRB1 BE THE PROTECTIVE LOCUS IN RHEUMATOID-ARTHRITIS
COULD HLA-DRB1 BE THE PROTECTIVE LOCUS IN RHEUMATOID-ARTHRITIS
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DOI：
10.1016/0167-5699(95)80181-2
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发表时间：
1995-06-01
期刊：
影响因子：
--
通讯作者：
DAVID, CS
中科院分区：
文献类型：
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作者：
ZANELLI, E;GONZALEZGAY, MA;DAVID, CS
在不同种族的广泛研究表明，类风湿关节炎（RA）的易感性与主要组织相容性复合体（MHC） HLA-DR β 1分子的第三高变区有关。Eric Zanelli， Miguel Gonzalez-Gay和Chella David基于最近在实验性小鼠胶原诱导关节炎模型中的发现，提出HLA-DR β 1位点与对RA的保护有关，而实际的致关节炎肽呈递分子是HLA-DQ。因此，RA的发展将取决于易感DQ等位基因和非保护性DRB1等位基因的表达，以及触发自身免疫过程的环境因素。
Extensive studies in different ethnic groups have associated the susceptibility to development of rheumatoid arthritis (RA) with the third hypervariable region of the major histocompatibility complex (MHC) HLA-DR beta 1 molecule. On the basis of recent findings in the experimental mouse model of collagen-induced arthritis, Eric Zanelli, Miguel Gonzalez-Gay and Chella David propose that the HLA-DR beta 1 locus is associated with protection to RA and that the actual arthritogenic peptide-presenting molecule is HLA-DQ. Thus, the development of RA would depend upon the expression of the susceptible DQ allele and the nonprotective DRB1 alleles, along with environmental factors that trigger the autoimmune process.