THE MESENCEPHALIC LOCOMOTOR REGION .1. ACTIVATION OF A MEDULLARY PROJECTION SITE
THE MESENCEPHALIC LOCOMOTOR REGION .1. ACTIVATION OF A MEDULLARY PROJECTION SITE
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DOI：
10.1016/0006-8993(87)90675-5
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发表时间：
1987-05-12
期刊：
影响因子：
2.9
通讯作者：
SKINNER, RD
中科院分区：
文献类型：
--
作者：
GARCIARILL, E;SKINNER, RD
我们实验室以前的解剖学研究已经证明了生理学上确定的中脑运动区（MLR）向中腹侧延髓的下行投射。在本研究中，该区域被电和化学激活以确定在前丘-后乳头横切猫中引起的运动事件的性质。对中腹侧延髓中的特定区域的低振幅（> 70 μ A）、高频（5-60 Hz）刺激引起在跑步机上运动的受控事件。在这个区域注射胆碱能激动剂也能引起短暂的运动。发现注射胆碱能拮抗剂可阻断由以下引起的运动：（1）电刺激相同区域;（2）注射胆碱能激动剂;或（3）电刺激MLR。注射P物质到延髓腹内侧被发现诱导运动的时间比注射胆碱能激动剂。这些研究结果表明，在生理上，一个主要的尾终止网站的MLR位于中腹侧延髓，并建议，至少有一部分的下行MLR预测采用乙酰胆碱和P物质作为神经递质。
Previous anatomical studies from our laboratories have demonstrated descending projections of the physiologically identified mesencephalic locomotor region (MLR) to the medioventral medulla. In the present study, this area was activated electrically and chemically to determine the nature of locomotor events elicited in the precollicular-postmammillary transected cat. Low-amplitude (> 70 .mu.A), high-frequency (5-60 Hz) stimulation of a specific region in the medioventral medulla elicited controlled episodes of locomotion on a treadmill. Injections of cholinergic agonists into this area also were found to elicit short episodes of locomotion. Injections of cholinergic antagonists were found to block locomotion elicited by: (1) electrical stimulation of the same area; (2) injections of cholinergic agonists; or (3) electrical stimulation of the MLR. Injections of substance P into the medioventral medulla were found to induce locomotion for longer periods of time than injections of cholinergic agonists. These findings demonstrate physiologically that a primary caudal termination site of the MLR is located in the medioventral medulla, and suggest that at least a portion of descending MLR projections employ acetylcholine and substance P as neurotransmitters.