Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
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DOI：
10.1038/ng2029
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发表时间：
2007-05-01
期刊：
影响因子：
30.8
通讯作者：
Greenspan, Ralph J.
中科院分区：
文献类型：
--
作者：
Dierick, Herman A.;Greenspan, Ralph J.
5-羟色胺（5-HT）和神经肽Y都已被证明会影响各种哺乳动物的行为（1-3），包括攻击性（4，5）。在这里，我们表明在果蝇，5-HT和神经肽F，神经肽Y的无脊椎动物同系物，调节侵略。我们发现，药物诱导的5-HT在苍蝇大脑中的增加增加侵略。升高5-HT的基因在多巴胺能电路重演这些药理学作用，而这些电路的基因沉默，使苍蝇的行为不响应药物诱导的5-HT的增加，但离开他们能够侵略。神经肽F（npf）回路的遗传沉默也增加了苍蝇的攻击性，这表明了对5-HT的相反调节。此外，这种神经肽F的作用似乎是独立的5-HT。这两个调节系统在苍蝇和老鼠的侵略暗示了一个显着程度的保守性和这种行为的深层分子根源。
Both serotonin (5-HT) and neuropeptide Y have been shown to affect a variety of mammalian behaviors(1-3), including aggression(4,5). Here we show in Drosophila melanogaster that both 5-HT and neuropeptide F, the invertebrate homolog of neuropeptide Y, modulate aggression. We show that drug-induced increases of 5-HT in the fly brain increase aggression. Elevating 5-HT genetically in the serotonergic circuits recapitulates these pharmacological effects, whereas genetic silencing of these circuits makes the flies behaviorally unresponsive to the drug-induced increase of 5-HT but leaves them capable of aggression. Genetic silencing of the neuropeptide F (npf) circuit also increases fly aggression, demonstrating an opposite modulation to 5-HT. Moreover, this neuropeptide F effect seems to be independent of 5-HT. The implication of these two modulatory systems in fly and mouse aggression suggest a marked degree of conservation and a deep molecular root for this behavior.