Preparation of Nano- and Micrometric Ceftazidime Particles with Supercritical Anti-Solvent Technique
Preparation of Nano- and Micrometric Ceftazidime Particles with Supercritical Anti-Solvent Technique
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DOI：
10.1021/jp8046664
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发表时间：
2008-08
影响因子：
3.7
通讯作者：
Shan-Chun Chang;Ming-Jer Lee;Ho-mu Lin
中科院分区：
文献类型：
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作者：
Shan-Chun Chang;Ming-Jer Lee;Ho-mu Lin
采用超临界抗溶剂（SAS）法制备了头孢他啶的纳米颗粒和微粒。研究了不同工艺参数对所得颗粒特性的影响。实验结果表明，产物的形态与颗粒形成阶段混合物在沉淀器中的相行为密切相关。无论是在压缩液体区还是在超临界区进行沉淀，都能得到粒径分布较窄的网状纳米球。然而，随着在临界区域附近进行降水，颗粒产品变得不均匀。在过热蒸汽区析出得到微球，而在汽液共存区形成致密膜和微粒。采用广角x射线散射（WAXS）、差示扫描量热仪（DSC）、热重分析仪（TGA）和傅里叶变换红外分光光度法（FTIR）对未处理的头孢他嗪和SAS沉淀样品进行表征。分析结果表明，经sas处理后的颗粒呈无定形，水含量明显降低。此外，SAS处理后的分子结构仍保持不变。
Nano- and microparticles of ceftazidime were prepared via a supercritical antisolvent (SAS) process. The influences of various processing parameters on the characteristics of the resultant particles were investigated. The experimental results revealed that the product's morphology closely correlated with the phase behavior of the mixtures in the precipitator during particle formation stage. Networked nanospheroids with narrow particle size distribution were produced when the precipitation was operated in either the compressed liquid region or in the supercritical region. However, the particulate products became less uniform as the precipitation was implemented near the critical region. While microspheroids were obtained as the precipitation was conducted in the superheated vapor region, dense films together with microparticles were formed in the vapor-liquid coexistence region. The untreated ceftazidime and the SAS precipitated samples were characterized with wide-angle X-ray scattering (WAXS), a differential scanning calorimeter (DSC), a thermogravimetric analyzer (TGA), and Fourier transform infrared spectrophotometry (FTIR). The analysis results indicated that the SAS-processed particles were amorphous and the water content was markedly reduced. Moreover, the molecular structure was still retained after the SAS processing.