Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder.
Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder.
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DOI：
10.1093/scan/nsw120
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发表时间：
2017-02-01
影响因子：
4.2
通讯作者：
Laucht M
中科院分区：
文献类型：
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作者：
Holz NE;Boecker-Schlier R;Buchmann AF;Blomeyer D;Jennen-Steinmetz C;Baumeister S;Plichta MM;Cattrell A;Schumann G;Esser G;Schmidt M;Buitelaar J;Meyer-Lindenberg A;Banaschewski T;Brandeis D;Laucht M
童年家庭逆境（CFA）增加了行为障碍（CD）的风险，并与腹侧纹状体（VS）和杏仁核等情感处理区域的改变有关。然而，到目前为止，还没有研究表明CFA和CD在同一样本中的神经会聚效应。在25岁时，功能性MRI数据在两个情感任务，即奖励（N = 171）和面部匹配范例（N = 181）和解剖扫描（N = 181）中获得右手目前健康的参与者的流行病学研究，从出生以来。儿童时期的CFA使用标准化的父母访谈来确定。通过诊断性访谈（2-19岁）获得儿童期和青少年期的破坏行为和CD诊断，通过问卷调查（15岁和19岁）评定气质奖赏依赖。CFA预测CD和杏仁核体积增加。CFA和CD暴露与奖励预期期间VS反应降低和面孔匹配期间杏仁核活动减弱相关。CD介导CFA对脑活动的影响。气质奖赏依赖与CFA、CD呈负相关，与VS活性呈正相关。这些发现强调了CFA对后代情感处理的不利影响，并支持旨在减少儿童逆境因素的产后早期干预计划的重要性。
Childhood family adversity (CFA) increases the risk for conduct disorder (CD) and has been associated with alterations in regions of affective processing like ventral striatum (VS) and amygdala. However, no study so far has demonstrated neural converging effects of CFA and CD in the same sample. At age 25 years, functional MRI data during two affective tasks, i.e. a reward (N = 171) and a face-matching paradigm (N = 181) and anatomical scans (N = 181) were acquired in right-handed currently healthy participants of an epidemiological study followed since birth. CFA during childhood was determined using a standardized parent interview. Disruptive behaviors and CD diagnoses during childhood and adolescence were obtained by diagnostic interview (2–19 years), temperamental reward dependence was assessed by questionnaire (15 and 19 years). CFA predicted increased CD and amygdala volume. Both exposure to CFA and CD were associated with a decreased VS response during reward anticipation and blunted amygdala activity during face-matching. CD mediated the effect of CFA on brain activity. Temperamental reward dependence was negatively correlated with CFA and CD and positively with VS activity. These findings underline the detrimental effects of CFA on the offspring's affective processing and support the importance of early postnatal intervention programs aiming to reduce childhood adversity factors.