An active inference theory of allostasis and interoception in depression
An active inference theory of allostasis and interoception in depression
复制标题
DOI：
10.1098/rstb.2016.0011
复制
发表时间：
2016-11-19
影响因子：
6.3
通讯作者：
Hamilton, Paul
中科院分区：
文献类型：
--
作者：
Barrett, Lisa Feldman;Quigley, Karen S.;Hamilton, Paul
在本文中，我们整合了内感受的预测编码和主动推理的最新理论和经验发展（包括预测性内感受编码模型）与建构情绪理论的工作假设，提出了一个生物学上合理的统一理论，将新陈代谢和能量调节（即别稳态），以及该调节的感觉后果（即内感受），在其核心。然后，我们考虑这种方法对理解抑郁症的影响。我们推测，抑郁症是一种变稳态障碍，其无数的症状是由一个“锁定”的大脑，这是相对不敏感的感官环境。最后，我们简要讨论了我们的方法可能揭示抑郁症治疗的新见解。这篇文章是主题问题的一部分“内感受超越稳态：影响，认知和心理健康”。
In this paper, we integrate recent theoretical and empirical developments in predictive coding and active inference accounts of interoception (including the Embodied Predictive Interoception Coding model) with working hypotheses from the theory of constructed emotion to propose a biologically plausible unified theory of the mind that places metabolism and energy regulation (i.e. allostasis), as well as the sensory consequences of that regulation (i.e. interoception), at its core. We then consider the implications of this approach for understanding depression. We speculate that depression is a disorder of allostasis, whose myriad symptoms result from a 'locked in' brain that is relatively insensitive to its sensory context. We conclude with a brief discussion of the ways our approach might reveal new insights for the treatment of depression.This article is part of the themed issue 'Interoception beyond homeostasis: affect, cognition and mental health'.