Diffusion tensor MRI to investigate dementias: a brief review
Diffusion tensor MRI to investigate dementias: a brief review
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DOI：
10.1016/j.mri.2007.03.017
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发表时间：
2007-07-01
影响因子：
2.5
通讯作者：
Cherubini, Andrea
中科院分区：
文献类型：
--
作者：
Bozzali, Marco;Cherubini, Andrea
扩散张量磁共振成像（DT-MRI）是一种强大的定量技术，能够检测体内脑组织的微观特征和异常。它已经成功地应用于许多神经系统疾病，如中风、多发性硬化症和脑肿瘤，提供了在病理基质上无法获得的信息。DT-MRI也被用于研究认知能力下降的患者，主要是那些患有阿尔茨海默病的患者。采用了几种图像分析方法，包括感兴趣区域、直方图、基于体素的分析和基于dt - mpi的神经束成像。组织损伤空间分布的特定模式及其与神经心理学测量的相关性已被报道。本文综述了DT-MRI在痴呆症研究中的应用。主要的临床结果和不同的图像分析方法将被概述和讨论。(c) 2007爱思唯尔公司版权所有。
Diffusion tensor magnetic resonance imaging (DT-MRI) is a powerful quantitative technique with the ability to detect in vivo microscopic characteristics and abnormalities of brain tissue. It has been successfully applied to a number of neurological conditions, such as stroke, multiple sclerosis and brain tumors, providing information otherwise inaccessible on the pathological substrates. DT-MRI has also been used to study patients with cognitive decline, mainly those with Alzheimer's disease. Several image-analysis approaches have been employed, including region of interest, histogram, voxel-based analyses and DT-MPI-based tractography. Specific patterns of spatial distribution of tissue damage and correlations with neuropsychological measures have been reported. This review focuses on the use of DT-MRI to investigate dementias. The main clinical results and the different methods of image analysis will be overviewed and discussed. (c) 2007 Elsevier Inc. All rights reserved.