Laryngeal mask ventilation with chest compression during neonatal resuscitation: randomized, non-inferiority trial in lambs.
Laryngeal mask ventilation with chest compression during neonatal resuscitation: randomized, non-inferiority trial in lambs.
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DOI：
10.1038/s41390-021-01820-z
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发表时间：
2022-09
影响因子：
3.6
通讯作者：
Rawat, Munmun
中科院分区：
文献类型：
--
作者：
Mani, Srinivasan;Gugino, Sylvia;Helman, Justin;Bawa, Mausma;Nair, Jayasree;Chandrasekharan, Praveen;Rawat, Munmun
有效的正压通气是新生儿复苏的关键因素。新生儿气管插管（ETT）需要大量的培训和经验，这是人为因素的挑战。在新生儿复苏初期，喉罩通气是一种安全可行的替代方法。然而，在胸部按压（CC）中使用它的证据有限。17只羔羊随机分为LMA或ETT通气组，脊髓闭塞导致心脏骤停。心脏骤停5分钟后，按照NRP的建议开始复苏。记录通气、氧合、全身及肺血流动力学参数，直至自动循环恢复（ROSC）或20分钟。两组的基线特征相似。LMA组ROSC发生率为75% (6/8)，ETT组为56% (5/9)（p = 0.74）。LMA组达到ROSC的中位（IQR）时间为6.85 min (6 min - 9.1 min)， ETT组为7.50 min (5.33 min - 18 min) （p = 0.65）。在本模型中，CC期LMA通气是可行的，且不逊色于ETT。
Effective positive pressure ventilation is a critical factor in newborn resuscitation. Neonatal endotracheal intubation (ETT) needs considerable training and experience, which poses a human factor challenge. Laryngeal mask airway (LMA) ventilation can be a secure and viable alternative during the initial stages of newborn resuscitation. However, there is limited evidence for its use during chest compression (CC). Seventeen lambs were randomized into LMA or ETT ventilation post cord occlusion induced cardiac arrest. After 5 minutes of cardiac arrest, resuscitation was initiated as per NRP recommendations. Ventilation, oxygenation, systemic and pulmonary hemodynamic parameters were recorded till return of spontaneous circulation (ROSC) or 20 minutes. Baseline characteristics were similar between the groups. The incidence of ROSC was 75% (6/8) in the LMA group and 56% (5/9) in the ETT group (p = 0.74). The median (IQR) time to achieve ROSC was 6.85 min (6 min – 9.1 min) in the LMA group and 7.50 min (5.33 min – 18 min) in the ETT group (p = 0.65). LMA ventilation during CC is feasible and non-inferior to ETT in this model.
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影响因子：
2.8
作者：
Zanardo V;Simbi A;Micaglio M;Cavallin F;Tshilolo L;Trevisanuto D
通讯作者：
Trevisanuto D
影响因子：
1.7
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通讯作者：
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通讯作者：
Nishisaki, Akira
影响因子：
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作者：
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Lakshminrusimha, Satyan
影响因子：
158.5
作者：
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通讯作者：
Tylleskar, Thorkild