Diabetes and the risk of developing Parkinson's disease in Denmark.
Diabetes and the risk of developing Parkinson's disease in Denmark.
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DOI：
10.2337/dc10-1333
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发表时间：
2011-05
期刊：
影响因子：
16.2
通讯作者：
Ritz B
中科院分区：
文献类型：
--
作者：
Schernhammer E;Hansen J;Rugbjerg K;Wermuth L;Ritz B
胰岛素有助于正常的大脑功能。先前的研究表明，中年糖尿病与神经退行性疾病（包括帕金森病）之间存在关联。使用丹麦人口登记，我们调查了糖尿病史或抗糖尿病药物的使用是否与帕金森病有关。从全国范围内丹麦医院登记的医院记录中，我们确定了2001年至2006年间首次诊断为帕金森病的1931例患者。我们从中央人口登记处随机抽取9651名人口控制对象，按出生年份和性别进行密度匹配。药房记录包括丹麦所有抗糖尿病和抗帕金森药物处方。通过logistic回归模型估计优势比（ORs）。根据一次或多次住院和/或门诊就诊的定义，患有糖尿病与患帕金森病的风险增加36%相关（or 1.36 [95% CI 1.08-1.71]）。同样，使用任何抗糖尿病药物定义的糖尿病与帕金森病风险增加35%相关（1.35[1.10-1.65]）。当糖尿病被定义为使用口服抗糖尿病药物时，女性的效应估计更强（2.92[1.34-6.36]），而当糖尿病被定义为任何抗糖尿病药物处方时，早发性帕金森病患者的风险最高（即60岁之前诊断出帕金森病；3.07[1.65-5.70]）。我们发现，糖尿病的诊断或接受的治疗与患帕金森病的风险增加显著相关，尤其是年轻发病的帕金森病。我们的研究结果表明这两种疾病之间有共同的病理生理途径。未来的研究应该考虑帕金森病发病的年龄。
Insulin contributes to normal brain function. Previous studies have suggested associations between midlife diabetes and neurodegenerative diseases, including Parkinson’s disease. Using Danish population registers, we investigated whether a history of diabetes or the use of antidiabetes drugs was associated with Parkinson’s disease. From the nationwide Danish Hospital Register hospital records, we identified 1,931 patients with a first-time diagnosis of Parkinson’s disease between 2001 and 2006. We randomly selected 9,651 population control subjects from the Central Population Registry and density matched them by birth year and sex. Pharmacy records comprising all antidiabetes and anti-Parkinson drug prescriptions in Denmark were available. Odds ratios (ORs) were estimated by logistic regression models. Having diabetes, as defined by one or more hospitalizations and/or outpatient visits for the condition, was associated with a 36% increased risk of developing Parkinson’s disease (OR 1.36 [95% CI 1.08–1.71]). Similarly, diabetes defined by the use of any antidiabetes medications was associated with a 35% increased Parkinson’s disease risk (1.35 [1.10–1.65]). When diabetes was defined as the use of oral antidiabetes medications, effect estimates were stronger in women (2.92 [1.34–6.36]), whereas when diabetes was defined as any antidiabetes drug prescription, patients with early-onset Parkinson’s disease were at highest risk (i.e., Parkinson’s disease diagnosed before the age of 60 years; 3.07 [1.65–5.70]). We found that a diagnosis of, or treatment received for, diabetes was significantly associated with an increased risk of developing Parkinson’s disease, especially younger-onset Parkinson’s disease. Our results suggest a common pathophysiologic pathway between the two diseases. Future studies should take age at Parkinson’s disease onset into account.