A Comprehensive Specimen-Specific Multiscale Data Set for Anatomical and Mechanical Characterization of the Tibiofemoral Joint.
A Comprehensive Specimen-Specific Multiscale Data Set for Anatomical and Mechanical Characterization of the Tibiofemoral Joint.
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DOI：
10.1371/journal.pone.0138226
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Erdemir A
中科院分区：
文献类型：
--
作者：
Chokhandre S;Colbrunn R;Bennetts C;Erdemir A
了解胫股关节力学在多个空间尺度是必不可少的发展有效的预防措施和治疗的病理和损伤管理。目前，在多个空间尺度上明显缺乏生物力学数据，例如，关节、组织和细胞鳞片。全面的多尺度数据可以提高对各种尺度上生物力学和解剖学标记之间关系的理解。此外，胫骨股关节的骨特异性多尺度数据可能有助于骨特异性计算模型的开发和验证，这可能有助于更全面地分析关节的生物力学行为。本研究描述了采集胫股关节多尺度解剖和生物力学数据的程序集合。磁共振成像用于获取关节尺度的解剖形态。机器人测试系统被用来量化关节水平的生物力学响应下的各种负载的情况。从相同样本中获得股骨和胫骨关节软骨、内侧和外侧韧带、前交叉韧带和后交叉韧带以及内侧和外侧副韧带的组织水平材料特性。还获得了所有组织类型的组织学数据，以测量大肠杆菌特异性细胞尺度信息，例如，细胞分布这项研究是第一次建立一个全面的多尺度数据集的肌肉骨骼关节和所提出的数据收集方法可以作为一个通用的模板，以指导收购的肌肉骨骼关节的特定的全面的多尺度数据。
Understanding of tibiofemoral joint mechanics at multiple spatial scales is essential for developing effective preventive measures and treatments for both pathology and injury management. Currently, there is a distinct lack of specimen-specific biomechanical data at multiple spatial scales, e.g., joint, tissue, and cell scales. Comprehensive multiscale data may improve the understanding of the relationship between biomechanical and anatomical markers across various scales. Furthermore, specimen-specific multiscale data for the tibiofemoral joint may assist development and validation of specimen-specific computational models that may be useful for more thorough analyses of the biomechanical behavior of the joint. This study describes an aggregation of procedures for acquisition of multiscale anatomical and biomechanical data for the tibiofemoral joint. Magnetic resonance imaging was used to acquire anatomical morphology at the joint scale. A robotic testing system was used to quantify joint level biomechanical response under various loading scenarios. Tissue level material properties were obtained from the same specimen for the femoral and tibial articular cartilage, medial and lateral menisci, anterior and posterior cruciate ligaments, and medial and lateral collateral ligaments. Histology data were also obtained for all tissue types to measure specimen-specific cell scale information, e.g., cellular distribution. This study is the first of its kind to establish a comprehensive multiscale data set for a musculoskeletal joint and the presented data collection approach can be used as a general template to guide acquisition of specimen-specific comprehensive multiscale data for musculoskeletal joints.