Corneal Confocal Microscopy: A New Technique for Early Detection of Diabetic Neuropathy
Corneal Confocal Microscopy: A New Technique for Early Detection of Diabetic Neuropathy
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DOI：
10.1007/s11892-013-0390-z
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发表时间：
2013-08-01
影响因子：
4.2
通讯作者：
Ziegler, D.
中科院分区：
文献类型：
--
作者：
Papanas, N.;Ziegler, D.
角膜共聚焦显微镜（CCM）是一种无创的活体角膜研究方法。它已越来越多地用于评估角膜基底下神经丛的形态。CCM具有良好的重复性，可能有助于糖尿病多发性神经病变的早期诊断。它也可能有助于记录治疗干预后早期神经纤维结构的有利变化。角膜神经病变在糖尿病多发神经病变患者中更为明显，并与其临床严重程度相关。CCM诊断多发性神经病变的敏感性和特异性为中高。CCM现在值得在大型纵向研究中进一步使用，以提供更多关于糖尿病神经病变的自然史和治疗效果的信息。此外，还需要一个更大的规范数据库。最后，技术进步有望使更大的角膜区域可视化，改善神经纤维量化，提高诊断准确性。
Corneal confocal microscopy (CCM) is a noninvasive method for the study of human cornea in vivo. It has increasingly been used to assess the morphology of the sub-basal corneal nerve plexus. CCM has good reproducibility and may contribute to the early diagnosis of diabetic polyneuropathy. It may also be useful to document favorable changes in nerve fiber structure early after therapeutic intervention. Corneal nerve pathology is more pronounced in patients with diabetic polyneuropathy and is associated with its clinical severity. The sensitivity and specificity of CCM for the diagnosis of polyneuropathy is moderate to high. CCM now merits further use in large longitudinal studies to provide more information on the natural history of diabetic neuropathy and effects of treatment. Moreover, there is a need for a larger normative database. Finally, technical progress is expected to enable visualization of larger corneal areas and improve nerve fiber quantification, increasing diagnostic accuracy.