hOR17-4 as a potential therapeutic target
hOR17-4 as a potential therapeutic target
复制标题
DOI：
10.1358/dnp.2004.17.3.829014
复制
发表时间：
2004-04-01
影响因子：
--
通讯作者：
Hatt, H
中科院分区：
文献类型：
--
作者：
Spehr, M;Hatt, H
十多年前，人类睾丸组织中嗅觉受体表达的意外发现引发了人们对这些趋化受体在成熟精子行为的各个方面，特别是精子趋化性中的潜在作用的猜测。最近，hOR17-4的鉴定提供了支持这一假设的第一个证据，hOR17-4是一种在各种生物测定中介导人类精子趋化的睾丸嗅觉受体。对受体分子接受范围的详细描述以及对强效受体拮抗剂的首次描述可以为未来在生育治疗中的应用提供基础，并在生殖和/或避孕方面产生重要影响。(C) 2004《科学》。版权所有。
More than a decade ago, the unexpected finding of olfactory receptor expression in human testicular tissue led to speculation about a potential role of these chemoreceptors in various aspects of mature sperm behavior, especially sperm chemotaxis. Recently, first evidence in favor of this hypothesis was provided by the identification of hOR17-4, a testicular olfactory receptor that mediates human sperm chemotaxis in various bioassays. A detailed characterization of the receptor's molecular receptive range as well as the first description of a potent receptor antagonist could provide the basis for future applications in fertility treatment with important consequences in procreation and/or contraception. (C) 2004 Prous Science. All rights reserved.