Global Similarity and Pattern Separation in the Human Medial Temporal Lobe Predict Subsequent Memory
Global Similarity and Pattern Separation in the Human Medial Temporal Lobe Predict Subsequent Memory
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DOI：
10.1523/jneurosci.4293-12.2013
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发表时间：
2013-03-27
影响因子：
5.3
通讯作者：
Wagner, Anthony D.
中科院分区：
文献类型：
--
作者：
LaRocque, Karen F.;Smith, Mary E.;Wagner, Anthony D.
关于内侧颞叶（MTL）结构在再认记忆中的作用存在着激烈的争论。使用高分辨率的功能磁共振成像和分析人类的模式相似性，我们研究了编码计算subserved MTL子区域。具体来说，我们测试的理论，MTL皮层支持记忆的编码重叠表示，而海马支持记忆的编码模式分离的表示。与这一观点相一致，编码模式相似性和随后的记忆之间的关系分离MTL皮层和海马：后来的记忆预测更大的跨项目模式相似性在嗅周皮层和海马旁皮层，但更大的模式独特性在海马。此外，通过比较神经模式引起的个别刺激，无论随后的记忆，我们发现，嗅周皮层和海马旁皮层表现出不同的内容敏感性多个刺激类别，而海马未能表现出内容敏感性。这些数据提供了新的证据，补充MTL编码计算有益于陈述性记忆。
Intense debate surrounds the role of medial temporal lobe (MTL) structures in recognition memory. Using high-resolution fMRI and analyses of pattern similarity in humans, we examined the encoding computations subserved by MTL subregions. Specifically, we tested the theory that MTL cortex supports memory by encoding overlapping representations, whereas hippocampus supports memory by encoding pattern-separated representations. Consistent with this view, the relationship between encoding pattern similarity and subsequent memory dissociated MTL cortex and hippocampus: later memory was predicted by greater across-item pattern similarity in perirhinal cortex and in parahippocampal cortex, but greater pattern distinctiveness in hippocampus. Additionally, by comparing neural patterns elicited by individual stimuli regardless of subsequent memory, we found that perirhinal cortex and parahippocampal cortex exhibited differential content sensitivity for multiple stimulus categories, whereas hippocampus failed to demonstrate content sensitivity. These data provide novel evidence that complementary MTL encoding computations subserve declarative memory.