Syn-selective vinylogous Kobayashi aldol reaction.
Syn-selective vinylogous Kobayashi aldol reaction.
复制标题
顺式选择性插烯小林醇醛反应。
作者：
Gerrit Symkenberg;M. Kalesse
小林醛反应已成为聚酮合成中的一个重要转变。该方法利用了埃文斯助剂的定向作用，并允许四碳段与两个附加甲基分支的立体选择性结合，在两个新形成的手性中心之间建立反关系。到目前为止，这种转变仅限于抗醇类产品。我们在这里提出了一个改进的协议，提供了相应的高同步选择性的醛醇产物。
The Kobayashi aldol reaction has become a prominent transformation in polyketide syntheses. This methodology takes advantage of the directing effects of the Evans auxiliary and allows the stereoselective incorporation of a four carbon segment with two additional methyl branches establishing an anti-relationship between the two newly formed chiral centers. So far this transformation was restricted to anti-aldol products. We present here a modified protocol that provides the corresponding aldol product with high syn-selectivity.
影响因子：
16.6
作者：
Evans, David A.;Dunn, Travis B.;Favor, David A.
通讯作者：
Favor, David A.