Ontogeny of morphine withdrawal in the rat.
Ontogeny of morphine withdrawal in the rat.
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大鼠吗啡戒断的个体发育。
DOI：
10.1037//0735-7044.109.6.1189
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发表时间：
1995
影响因子：
1.9
通讯作者：
Barr,GA
中科院分区：
文献类型：
--
作者：
Jones,KL;Barr,GA
本研究检测了7日龄至42日龄大鼠在催促吗啡戒断过程中的行为变化。其中一组大鼠每日两次注射硫酸吗啡(10.0 mg/kg)，连续6.5d。另一组7日龄大鼠接受较低剂量的吗啡(3.0 mg/kg)。对照组为注射生理盐水或未处理的幼犬(仅限7日龄幼崽)。在第7天，给目标幼犬注射生理盐水或纳曲酮(0.3-20.0 mg/kg)。在一个温暖的房间里观察断奶前的幼崽和幼崽。对42天龄的大鼠进行了单独测试。用纳曲酮测试吗啡处理的幼鼠显示出显著的行为变化，这些变化在不同的年龄有所不同。例如，在较年轻的老鼠身上可以观察到打滚、伸展、头部和爪子的移动，而在年龄较大的老鼠中，则会出现打洞、腹泻、跳跃、牙齿打颤和湿狗抖动的情况。这些数据表明，吗啡戒断大鼠表现出的戒断迹象符合大鼠的发育过程。(《心理信息数据库记录(C)2022年APA》，版权所有)
The present studies examined behavioral changes during precipitated morphine withdrawal in 7-to 42-day-old rat pups. One group of rats was injected with morphine sulfate (10.0 mg/kg) twice daily for 6.5 days. Another group of 7-day-old rats received a lower dose of morphine (3.0 mg/kg). Controls were saline injected or untreated litters (7-day-old pups only). On Day 7, a target pup was injected with saline or naltrexone (0.3–20.0 mg/kg). Preweaning pups were observed in a warm chamber with the litter. Forty-two-day-old rats were tested individually. Morphine-treated pups tested with naltrexone showed significant alterations in behavior that varied at different ages. For example, rolling, stretching, and head and paw moves were observed at the younger ages, whereas burrowing, diarrhea, jumps, teeth chatter, and wet dog shakes occurred in the older rats. These data indicate that morphine-abstinent rats demonstrate withdrawal signs that are within the developmental repertoire of the rat.(PsycInfo Database Record (c) 2022 APA, all rights reserved)