The chondrocyte
The chondrocyte
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DOI：
10.1016/s1357-2725(02)00301-1
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发表时间：
2003-04-01
影响因子：
4
通讯作者：
Francis-West, P
中科院分区：
文献类型：
--
作者：
Archer, CW;Francis-West, P
软骨细胞是软骨的常驻细胞，软骨是胚胎中的突出组织，充当骨骼元件发育的模板。在成人中，永久软骨的分布受到更多限制，并且对于机械支撑、生长和运动是必要的。细胞被分离在既不血管化也不受神经支配的大量细胞外基质（ECM）中。因此，营养物/废物交换通过扩散发生，因此，在正常和病理条件下，细胞在低氧张力环境中存在的能力是独特的。部分由于这些特性，组织具有较低的修复潜力，在关节软骨的情况下，使组织易于发生退行性疾病，如关节炎，这是一个重要的临床问题。细胞因子细胞质分离。高基质/细胞体积比。骨骼成熟后不分裂，除非在病理过程中。身体生长的主要贡献者。大多数能量需求通过糖酵解获得。(C)2003爱思唯尔科技有限公司版权所有。
The chondrocyte is the resident cell of cartilage that is a prominent tissue in the embryo acting as a template for the development of skeletal elements. In the adult, the distribution of permanent cartilage is much more restricted and is necessary for mechanical support, growth and movement. The cell is isolated within a voluminous extracellular matrix (ECM) that is neither vascularised nor innervated. As a result, nutrient/waste exchange occurs through diffusion and, consequently, under normal and pathological conditions, the cell is unique in its ability to exist in a low oxygen tension environment. Partly as a result of these properties, the tissue has a low reparative potential that, in the case of articular cartilage, predisposes the tissue to degenerative conditions such as arthritis that is a significant clinical problem.CellfactsCytoplasmically isolated.High matrix/cell volume ratio.Do not divide after skeletal maturity unless during pathology.Major contributor to growth of the body. Most energy requirements obtained through glycolysis. (C) 2003 Elsevier Science Ltd. All rights reserved.