Eliminating Solid Phase Extraction with Large-Volume Injection LC/MS/MS: Analysis of Illicit and Legal Drugs and Human Urine Indicators in US Wastewaters
Eliminating Solid Phase Extraction with Large-Volume Injection LC/MS/MS: Analysis of Illicit and Legal Drugs and Human Urine Indicators in US Wastewaters
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DOI：
10.1021/es802309v
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发表时间：
2008-12-01
影响因子：
11.4
通讯作者：
Field, Jennifer
中科院分区：
文献类型：
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作者：
Chiaia, Aurea C.;Banta-Green, Cale;Field, Jennifer
开发并优化了大体积 (1800,A) 进样 (LVI)，然后进行液相色谱/串联质谱分析，以消除样品制备步骤中离线和在线固相萃取的需要。对城市原始进水进行离心，然后进行 LVI 优化，以用于城市废水中非法药物和相关物质的常规测定。该方法的准确性通过浓度范围为 4 至 3 500 000 ng/L 的分析物的标准添加来证明。精度，以相对标准偏差表示
Large-volume (1800,A) injection (LVI) followed by liquid chromatography/tandem mass spectrometry was developed and optimized to eliminate the need for off- and on-line solid phase extraction as a sample preparation step. Centrifugation of raw municipal influent followed by LVI was optimized for the routine determination of illicit drugs and related substances in municipal wastewaters. The accuracy of the method is demonstrated by standard addition for analytes with concentrations ranging from 4 to 3 500 000 ng/L. Precision, as indicated by relative standard deviation is