Creative interior design by Plasmodium falciparum: Lipid metabolism and the parasite's secret chamber
Creative interior design by Plasmodium falciparum: Lipid metabolism and the parasite's secret chamber
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恶性疟原虫的创意室内设计：脂质代谢和寄生虫的密室
DOI：
10.1016/j.parint.2021.102369
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发表时间：
2021
影响因子：
1.9
通讯作者：
Miyazaki Shinya
中科院分区：
文献类型：
--
作者：
Tokumasu Fuyuki;Hayakawa Eri H.;Fukumoto Junpei;Tokuoka Suzumi M.;Miyazaki Shinya
疟原虫隐藏在宿主红细胞内，并通过这些细胞的三层膜结构建立必要的物流系统。为了建立这一系统，需要脂质代谢来进行脂质的重新合成以及细胞外脂质和红细胞脂质成分的再循环。胆固醇的供应取决于其从细胞外环境和红细胞质中的摄取，但磷脂可以自行合成。脂质物质的这种差异产生在寄生红细胞的脂质谱中产生独特的修饰，这反过来可能影响细胞器和囊泡的生物物理和/或机械性质以及它们之间的通信。局部膜特性的变化可能会影响寄生虫衍生蛋白等各种分子的运输，因为分泌、囊泡融合和萌芽的效率部分取决于脂质谱。全面了解寄生虫的脂质代谢和脂质膜的生物物理学提供了有关这些病原体的基本知识，并可能导致新的抗疟疾药物。
Malaria parasites conceal themselves within host erythrocytes and establish a necessary logistics system through the three-membrane layered structures of these cells. To establish this system, lipid metabolism is needed for thede novosynthesis of lipids and the recycling of extracellular lipids and erythrocyte lipid components. Cholesterol supply depends on its uptake from the extracellular environment and erythrocyte cytoplasm, but phospholipids can be synthesized on their own. This differential production of lipid species creates unique modifications in the lipid profile of parasitized erythrocytes, which in turn may influence the biophysical and/or mechanical properties of organelles and vesicles and communication among them. Variations in local membrane properties possibly influence the transportation of various molecules such as parasite-derived proteins, because efficiencies in secretion, vesicle fusion and budding are partly determined by the lipid profiles. Comprehensive understanding of the parasite's lipid metabolism and the biophysics of lipid membranes provides fundamental knowledge about these pathogenic organisms and could lead to new anti-malarials.