Evaluation of potential factors affecting the measurement of cerebrovascular reactivity by near-infrared spectroscopy.
Evaluation of potential factors affecting the measurement of cerebrovascular reactivity by near-infrared spectroscopy.
复制标题
影响近红外光谱测量脑血管反应性的潜在因素的评估。
DOI：
10.1042/cs0950497
复制
发表时间：
1998
期刊：
影响因子：
6
通讯作者：
M. Ferrari
中科院分区：
文献类型：
--
作者：
R. Totaro;G. Barattelli;V. Quaresima;A. Carolei;M. Ferrari
1.近红外（IR）光谱法基于皮肤、颅骨和大脑对近红外区域（700-1100 nm）中的光的相对透明度以及血红蛋白的氧依赖性组织吸收变化。我们评估了可能影响近红外光谱检测CO2脑血管反应性可靠性的最相关因素（重复性、静脉回流、年龄和性别）。该方案包括3分钟的基线，3分钟的高碳酸血症（5%CO2的空气）和2分钟的恢复。同时进行经颅多普勒超声测量。在1小时后对27名受试者重复CO2反应性测试以评估再现性。还在不同体位（仰卧、35度特伦德伦伯卧位和35度反向特伦德伦伯卧位）以及吸入CO2.4逐渐增加时评价CO2反应性。近红外光谱和经颅多普勒超声参数的变化与潮气末CO2的变化显著相关（P<0.005）。近红外光谱参数的反应性指数与流速呈显著正相关（P<0.01）。还发现脱氧血红蛋白（rI=0.76），氧合血红蛋白（rI=0.68）和流速（rI=0.60）反应性指数的重复性高。不同体位的反应性指标间差异无统计学意义（P>0.05）。随着年龄的增长，氧合血红蛋白和脱氧血红蛋白的反应指数分别下降（P<0.05）和上升（P<0.01）。5.我们发现，近红外光谱是一种可靠的和可重复的方法，脑血管反应性的评价，并可能被认为是适当的验证后，脑血管疾病患者的评估。
1.Near-infrared (IR) spectroscopy is based on the relative transparency of skin, skull and brain to the light in the near-IR region (700-1100 nm) and on the oxygen-dependent tissue absorption changes of haemoglobin.2. We evaluated the most relevant factors (reproducibility, venous return, age and sex) that might affect reliability of near-IR spectroscopy to test CO2 cerebrovascular reactivity.3.Thirty-four healthy volunteers were enrolled in the study. The protocol consisted of a 3-min baseline, a 3-min hypercapnia (5% CO2 in air) and a 2-min recovery. Transcranial Doppler sonography measurements were simultaneously performed. The CO2 reactivity test was repeated on 27 subjects after 1 h to assess reproducibility. CO2 reactivity was also evaluated at different body positions (supine, 35 degrees Trendelenburg and 35 degrees reverse Trendelenburg), and over a gradual increase of the inspired CO2.4. Changes in near-IR spectroscopy and transcranial Doppler sonography parameters were significantly correlated with variations of end-tidal CO2 (P<0.005). A significant correlation between the reactivity indexes of near-IR spectroscopy parameters and flow velocity was also found (P<0.01). A high reproducibility was also found for deoxyhaemoglobin (rI=0.76), oxyhaemoglobin (rI=0.68) and flow velocity (rI=0.60) reactivity indexes. No significant differences between the reactivity indexes of different body positions were found (P>0.05). The reactivity index of oxyhaemoglobin and deoxyhaemoglobin decreased (P<0.05) and increased (P<0.01) with age respectively.5. We found that near-IR spectroscopy is a reliable and reproducible method for the evaluation of cerebrovascular reactivity and might be considered, after appropriate validation, for the assessment of patients with cerebrovascular disease.