FURTHER EVIDENCE FOR AN INHIBITORY ROLE OF CENTRAL 5-HT IN MALE-RAT SEXUAL-BEHAVIOR
FURTHER EVIDENCE FOR AN INHIBITORY ROLE OF CENTRAL 5-HT IN MALE-RAT SEXUAL-BEHAVIOR
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DOI：
10.1007/bf00428106
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发表时间：
1980-01-01
影响因子：
3.4
通讯作者：
SVENSSON, L
中科院分区：
文献类型：
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作者：
AHLENIUS, S;LARSSON, K;SVENSSON, L
5-羟色胺（5-HT）再摄取抑制剂zimelidine （10 mg/kg，预测1.5 h）或alaproclate （20 mg/kg，预测1.5 h）对阈下剂量的5-羟色胺（5-HTP） （12.5 mg/kg，预测1 h）治疗的雄性大鼠产生射精潜伏期和射精后间隔的延长。5-羟色胺诱导的射精潜伏期延长（预测1 h前50 mg/kg）可通过施用5-羟色胺受体阻滞剂美高林（预测1.5 h前1 mg/kg）有效抵消。所有动物均用外周芳香氨基酸脱羧酶抑制剂处理；这些影响是中心根源。中枢5-羟色胺抑制雄性大鼠性行为。
The 5-hydroxytryptamine (5-HT) reuptake inhibitors zimelidine (10 mg/kg i.p. 1.5 h pretest) or alaproclate (20 mg/kg i.p. 1.5 h pretest) produced a prolongation of the ejaculation latency and of the post-ejaculatory interval in male rats treated with a subthreshold dose of 5-hydroxytryptophan (5-HTP) (12.5 mg/kg i.p. 1 h pretest). The 5-HTP-induced (50 mg/kg i.p. 1 h pretest) prolongation of ejaculatory latency was effectively counteracted by administration of the 5-HT receptor blocking agent metergoline (1 mg/kg i.p. 1.5 h pretest). All animals were treated with an inhibitor of peripheral aromatic amino acid decarboxylase; the effects are of central origin. Central 5-HT inhibits male rat sexual behavior.