Neuroendocrine responses regulating susceptibility and resistance to autoimmune/inflammatory disease in inbred rat strains.
Neuroendocrine responses regulating susceptibility and resistance to autoimmune/inflammatory disease in inbred rat strains.
复制标题
神经内分泌反应调节近交大鼠品系对自身免疫/炎症疾病的易感性和抵抗力。
DOI：
10.1034/j.1600-065x.2001.1840118.x
复制
发表时间：
2001
影响因子：
8.7
通讯作者：
Sternberg,E
中科院分区：
文献类型：
--
作者：
Tonelli,L;Webster,JI;Rapp,KL;Sternberg,E
啮齿类动物炎症和自身免疫性疾病模型已成为研究神经内分泌生理学与免疫反应相互作用的重要工具。大鼠特别有用的部分原因是，与其他物种相比，大多数自身免疫性/炎症性疾病的大鼠模型是诱导的而不是自发的。这允许对与暴露于抗原或促炎触发物相关的神经内分泌系统进行系统和受控的操作。最常用的免疫激发包括脂多糖诱导的败血性休克、角叉菜胶诱导的局部炎症和佐剂或细菌细胞壁诱导的关节炎。通过分析不同品系的大鼠和小鼠对这些挑战的反应，可以定义神经内分泌和免疫系统之间的关系，并确定这些连接赋予自身免疫性和炎症性疾病易感性和抵抗力的一些机制。本综述将讨论从啮齿动物生理学获得的数据，表明这些疾病的易感性或耐药性的一个重要组成部分是由于神经内分泌下丘脑-垂体-肾上腺轴的免疫反应的调节功能障碍。特别是，室旁核的神经元在确定自身免疫性和炎症性疾病的易感性或抵抗力的重要性将进行讨论。
Rodent animal models of inflammatory and autoimmune disease have been important tools in the study of the interaction between neuroendocrine physiology and the immune responses. The rat has been particularly useful in part because, in contrast to other species, most rat models of autoimmune/inflammatory disease are induced rather than spontaneous. This allows for systematic and controlled manipulations of the neuroendocrine system in relation to exposure to the antigen or pro‐inflammatory trigger. The most frequently used immune challenges include lipopolysaccharide‐induced septic shock, carrageenan‐induced local inflammation and adjuvant or bacterial cell wall‐induced arthritis. By analyzing the responses to these challenges in different strains of rats and mice it has been possible to define the relationships between the neuroendocrine and immune systems and to identify some mechanisms through which these connections confer susceptibility and resistance to autoimmune and inflammatory diseases. The present review will discuss data obtained from rodent physiology, indicating that an important component in the susceptibility or resistance to development of these diseases is due to dysfunctional regulation of the immune response by the neuroendocrine hypothalamic–pituitary–adrenal axis. In particular, the importance of neurons of the paraventricular hypothalamic nucleus in determining susceptibility or resistance to autoimmune and inflammatory disease will be discussed.