Prevalence and determinants of Campylobacter infection among under five children with acute watery diarrhea in Mwanza, North Tanzania
Prevalence and determinants of Campylobacter infection among under five children with acute watery diarrhea in Mwanza, North Tanzania
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DOI：
10.1186/2049-3258-72-17
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发表时间：
2014-05-30
影响因子：
3.3
通讯作者：
Mshana, Stephen
中科院分区：
文献类型：
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作者：
Deogratias, Anna-Pendo;Mushi, Martha;Mshana, Stephen
背景：弯曲杆菌病是一种在全球范围内观察到的人畜共患细菌性疾病，已成为人类细菌性胃肠炎最常见的病因。本研究旨在确定坦桑尼亚姆万扎市5岁以下儿童急性水样腹泻患者中弯曲杆菌感染的患病率及其影响因素。方法：这项以医院为基础的横断面研究在姆万扎市布甘多医疗中心(BMC)和塞口·图雷医院进行。2012年10月至2013年4月期间符合纳入标准的所有五岁以下住院患者和门诊患者都参加了这项研究。使用标准化的数据收集工具获得人口统计学和临床数据。采集粪便标本进行革兰氏染色和弯曲杆菌培养。在普雷斯顿选择性琼脂媒体上。此外，所有患者都进行了疟疾和HIV检测的血液玻片检查。结果：共有300名儿童入选，年龄中值为12个月[四分位数范围，8-19个月]。其中169例(56.5%)来自BMC，131例(43.7%)来自Seou-Toure医院。170名(56.7%)的参与儿童为男性。在300例5岁以下儿童急性水样腹泻中，发现29例(9.7%)有弯曲杆菌感染。Seou Toure医院感染弯曲杆菌的儿童数量明显高于BMC[16.0%(21/29)比4.7%(8/29)，p=0.002]。年龄大于2岁独立预测弯曲杆菌感染(OR：2.9，95%CI1.1-7.7，p=0.0037)。在30例恶性疟原虫血片阳性的患者中，20.0%的患者同时存在弯曲杆菌感染(OR：3.90，95%CI1.2~10.1，p=0.021)。结论：姆万扎市5岁以下儿童急性水样腹泻患者中弯曲菌感染相对较低，且与疟疾切片阳性和2岁以上儿童独立相关。需要进一步的研究来分型最流行的弯曲杆菌种类，并确定它们的抗生素敏感性模式。
Background: Campylobacteriosis, a zoonotic bacterial disease observed world-wide, is becoming the most commonly recognized cause of bacterial gastroenteritis in humans. This study was done to determine the prevalence and determinants of Campylobacter infection among under-fives with acute watery diarrhea in Mwanza City, Tanzania.Method: This cross-sectional hospital-based study was conducted at Bugando Medical Centre (BMC) and Sekou Toure Hospital in Mwanza City. All inpatients and outpatients under-fives who met the inclusion criteria from October 2012 to April 2013 were enrolled in the study. Demographic and clinical data were obtained using standardized data collection tools. Stool samples were collected for gram staining and culture for Campylobacter spp. on Preston selective agar media. In addition, blood slides for malaria and HIV tests were done to all patients.Results: A total of 300 children were enrolled with a median age of 12 [interquartile range, 8-19] months. Of these, 169 (56.5%) were from BMC and 131 (43.7%) from Sekou-Toure hospital. One hundred and seventy (56.7%) of the participating children were male. Of 300 under-fives with acute watery diarrhea, 29 patients (9.7%) were found to have Campylobacter infection. A significant higher number of children with Campylobacter infection were found in Sekou Toure hospital compared to BMC [16.0% (21/29) versus 4.7% (8/29), p = 0.002)]. Age above 2 years was independently found to predict campylobacter infection (OR: 2.9, 95% CI 1.1-7.7, p = 0.0037). Of 30 patients with a positive blood slide for Plasmodium falciparum, 20.0% were also positive for Campylobacter infection (OR: 3.9, 95% CI 1.2-10.1, p = 0.021).Conclusion: Campylobacter infection shows a comparatively low prevalence in under-fives with acute watery diarrhea in Mwanza city and is independently associated with positive slides for malaria and an age above 2 years. Further studies are needed to type the most prevalent Campylobacter species and to determine their antibiotic susceptibility pattern.