Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin-Yang Collaboration.
Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin-Yang Collaboration.
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DOI：
10.3390/ijms23115887
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发表时间：
2022-05-24
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
细胞通信网络因子（Cellular communication network factor， CCN） 2和3是CCN家族的成员，在微环境中与多种生物分子相互作用下，协调多种组织和器官的发育。尽管它们具有惊人的结构相似性，但这两个成员在活组织中表现出截然不同的分子功能和时空出现。通常，CCN2促进细胞生长，而CCN3抑制细胞生长。在产生CCN2的地方，CCN3消失。然而，这两种蛋白质协同合作，以一种阴阳的方式执行它们的任务。CCN2和CCN3的明显功能对抗可以归因于它们的直接分子相互作用和对两者共享的辅因子的干扰。近年来的研究揭示了CCN2和CCN3之间相互负调控的系统。此外，CCN2和CCN3的同步、双向调控体系也正在被阐明。特别值得注意的是，这些调节被发现与糖酵解密切相关，糖酵解是能量代谢的基本过程。本文描述了在软骨发育/再生和纤维化中常见的CCN2和CCN3的阴阳协同作用的分子相互作用和代谢基因调控。
Cellular communication network factor (CCN) 2 and 3 are the members of the CCN family that conduct the harmonized development of a variety of tissues and organs under interaction with multiple biomolecules in the microenvironment. Despite their striking structural similarities, these two members show contrastive molecular functions as well as temporospatial emergence in living tissues. Typically, CCN2 promotes cell growth, whereas CCN3 restrains it. Where CCN2 is produced, CCN3 disappears. Nevertheless, these two proteins collaborate together to execute their mission in a yin–yang fashion. The apparent functional counteractions of CCN2 and CCN3 can be ascribed to their direct molecular interaction and interference over the cofactors that are shared by the two. Recent studies have revealed the mutual negative regulation systems between CCN2 and CCN3. Moreover, the simultaneous and bidirectional regulatory system of CCN2 and CCN3 is also being clarified. It is of particular note that these regulations were found to be closely associated with glycolysis, a fundamental procedure of energy metabolism. Here, the molecular interplay and metabolic gene regulation that enable the yin–yang collaboration of CCN2 and CCN3 typically found in cartilage development/regeneration and fibrosis are described.
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影响因子：
4
作者：
Cordova, Gonzalo;Rochard, Alice;Brandan, Enrique
通讯作者：
Brandan, Enrique
影响因子：
13.3
作者：
Dziadzio, M;Usinger, W;Stratton, R
通讯作者：
Stratton, R
影响因子：
0.7
作者：
Batmunkh, Rentsenkhand;Nishioka, Yasuhiko;Sone, Saburo
通讯作者：
Sone, Saburo
转化生长因子β控制椎间盘核细胞中的CCN3表达。
影响因子：
--
作者：
Tran, Cassie M.;Smith, Harvey E.;Symes, Aviva;Rittie, Laure;Perbal, Bernard;Shapiro, Irving M.;Risbud, Makarand V.
通讯作者：
Risbud, Makarand V.
DOI：
10.1083/jcb.114.6.1285
发表时间：
1991-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bradham DM;Igarashi A;Potter RL;Grotendorst GR
通讯作者：
Grotendorst GR