Susceptibility of Legionella pneumophila to twenty antimicrobial agents
Susceptibility of Legionella pneumophila to twenty antimicrobial agents
复制标题
嗜肺军团菌对二十种抗菌药物的敏感性
DOI：
10.1128/aac.18.3.403
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发表时间：
1980
影响因子：
4.9
通讯作者：
R. Meyer
中科院分区：
文献类型：
--
作者：
P. Edelstein;R. Meyer
采用琼脂稀释法对33株嗜肺军团菌（除1株外均为临床分离株）的20种抗菌药物进行了检测。红霉素、利福平和罗萨霉素是最具活性的试验药物。氨基糖苷类、氯霉素和头孢西丁在低浓度下也能抑制微生物。其他药物，包括氧杂内酰胺、头孢哌酮和头孢菌素，表现出中度至轻度活性。四环素、强力霉素和米诺环素在活性炭-酵母膏培养基中明显失活。在大多数测试的抗菌剂中观察到轻微的接种物依赖性，特别是β-内酰胺类药物。疾病控制中心提供的储备菌株和最近的临床分离株之间的敏感性没有一致的差异，但有一些药物的显着差异。考虑到接种量、菌株变异和所用培养基的影响，药敏试验需要标准化。
Thirty-three isolates of Legionella pneumophila, all except one of which were clinical isolates, were tested against 20 antimicrobial agents by using an agar dilution technique. Erythromycin, rifamp]in, and rosaramycin were the most active agents tested. Aminoglycosides, chloramphenicol, and cefoxitin also inhibited the organisms at low concentrations. Other agents, including moxalactam, cefoperazone, and cephalosporins, exhibited moderate to little activity. Tetracycline, doxycycline and minocyeline were apparently inactivated by charcoal-yeast extract medium. There was slight inoculum dependence noted with most of the antimicrobials tested, particularly the beta-lactam agents. There was no consistent difference in susceptibility between Center for Disease Control-supplied stock strains and recent clinical isolates, but there were marked differences with some agents. Susceptibility testing needs to be standardized in view of the influence of inoculum size, strain variation, and the medium used.