A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
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DOI：
10.1073/pnas.95.1.258
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发表时间：
1998-01-06
影响因子：
11.1
通讯作者：
Williams, LT
中科院分区：
文献类型：
--
作者：
Gunn, MD;Tangemann, K;Williams, LT
幼稚淋巴细胞优先归巢到次级淋巴器官被认为涉及到趋化因子的作用，但没有趋化因子被证明具有介导这一过程所需的表达模式或活性。在这里，我们展示了EST数据库中代表的趋化因子，次级淋巴组织趋化因子（SLC），在淋巴结和Peyer's斑块的高内皮小静脉中表达，在脾脏、淋巴结和Peyer's斑块的T细胞区域。也存在于多个器官的淋巴内皮中。SLC是一种高效的淋巴细胞趋化剂，对幼稚T细胞具有优先活性。此外，SLC通过β - 2整合素与对抗受体、细胞间粘附分子-1的结合诱导幼稚T淋巴细胞的坚定粘附，这是淋巴细胞募集的必要步骤，SLC是第一个被证明具有介导淋巴细胞向次级淋巴器官归巢所需特征的趋化因子。淋巴内皮中SLC的表达提示淋巴细胞从组织向传出淋巴的迁移可能是由SLC分子介导的一个活跃过程。
Preferential homing of naive lymphocytes to secondary lymphoid organs is thought to involve the action of chemokines, yet no chemokine has been shown to have either the expression pattern or the activities required to mediate this process, Here we show that a chemokine represented in the EST database, secondary lymphoid-tissue chemokine (SLC), is expressed in the high endothelial venules of lymph nodes and Peyer's patches, in the T cell areas of spleen, lymph nodes, and Peyer's patches, and in the lymphatic endothelium of multiple organs. SLC is a highly efficacious chemoattractant for lymphocytes with preferential activity toward naive T cells, Moreover, SLC induces firm adhesion of naive T lymphocytes via beta 2 integrin binding to the counter receptor, intercellular adhesion molecule-1, a necessary step for lymphocyte recruitment, SLC is the first chemokine demonstrated to have the characteristics required to mediate homing of lymphocytes to secondary lymphoid organs, In addition, the expression of SLC in lymphatic endothelium suggests that the migration of lymphocytes from tissues into efferent lymphatics may be an active process mediated by this molecule.