Delay-multiply-and-sum-based synthetic aperture focusing in photoacoustic microscopy
Delay-multiply-and-sum-based synthetic aperture focusing in photoacoustic microscopy
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DOI：
10.1117/1.jbo.21.3.036010
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发表时间：
2016-03-01
影响因子：
3.5
通讯作者：
Kim, Chulhong
中科院分区：
文献类型：
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作者：
Park, Jongin;Jeon, Seungwan;Kim, Chulhong
我们提出了一个改进的版本的合成孔径聚焦技术（SAFT）的基础上延迟乘和算法的声学分辨率光声显微镜（AR-PAM）。在该方法中，来自多条扫描线的光声（PA）信号被组合地耦合、相乘，然后求和。这个过程可以被认为是每个扫描线中的PA信号的相关操作，因此PA信号之间的空间相干信息可以被有效地提取。通过将该方法应用于常规AR-PAM中，与先前开发的SAFT估计的横向分辨率和离焦区域的信噪比相比，分别得到了很大的改善，从而实现了成像焦区的扩展。我们的幻影和在体成像实验证明了我们提出的方法的有效性。(C)2016年，美国光电仪器工程师学会（SPIE）
We propose an improved version of a synthetic aperture focusing technique (SAFT) based on a delay-multiply-and-sum algorithm for acoustic-resolution photoacoustic microscopy (AR-PAM). In this method, the photoacoustic (PA) signals from multiple scan-lines are combinatorially coupled, multiplied, and then summed. This process can be considered a correlation operation of the PA signals in each scan-line, so the spatial coherent information between the PA signals can be efficiently extracted. By applying this method in conventional AR-PAM, lateral resolution and signal-to-noise ratio in out-of-focus regions are much improved compared with those estimated from the previously developed SAFT, respectively, thereby achieving the extension of the imaging focal region. Our phantom and in vivo imaging experiments prove the validity of our proposed method. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)