The Drosophila ovarian and testis stem cell niches:: Similar somatic stem cells and signals
The Drosophila ovarian and testis stem cell niches:: Similar somatic stem cells and signals
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DOI：
10.1016/j.devcel.2005.08.012
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发表时间：
2005-10-01
影响因子：
11.8
通讯作者：
Spradling, AC
中科院分区：
文献类型：
--
作者：
Decotto, E;Spradling, AC
果蝇卵巢和睾丸顶端的干细胞龛在两个主要方面被认为是不同的。虽然两者都含有生殖系干细胞，但睾丸龛也含有“囊肿祖细胞”干细胞，其分裂产生体细胞，包裹发育中的生殖细胞。此外，虽然两个小生境都利用BMP信号，但睾丸小生境需要关键的JAK/STAT信号。我们现在通过谱系标记显示，卵巢小生境也包含第二种类型的干细胞。这些“护送干细胞”在形态上类似于睾丸囊肿祖细胞，它们的子细胞在卵泡形成时经历凋亡之前包裹发育中的囊肿。此外，我们发现JAK/STAT信号在卵巢生态位功能中也起着关键作用，并在护送细胞内起作用。这些观察结果揭示了男性和女性性腺干细胞小生境的惊人相似性，并表明它们在很大程度上受共同机制的支配。
The stem cell niches at the apex of Drosophila ovaries and testes have been viewed as distinct in two major respects. While both contain germline stem cells, the testis niche also contains "cyst progenitor" stem cells, which divide to produce somatic cells that encase developing germ cells. Moreover, while both niches utilize BMP signaling, the testis niche requires a key JAK/STAT signal. We now show, by lineage marking, that the ovarian niche also contains a second type of stem cell. These "escort stem cells" morphologically resemble testis cyst progenitor cells and their daughters encase developing cysts before undergoing apoptosis at the time of follicle formation. In addition, we show that JAK/STAT signaling also plays a critical role in ovarian niche function, and acts within escort cells. These observations reveal striking similarities in the stem cell niches of male and female gonads, and suggest that they are largely governed by common mechanisms.