Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster.
Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster.
复制标题
果蝇的实验室菌株中的性二态基因表达可变。
DOI：
10.1186/1471-2164-8-454
复制
发表时间：
2007-12-10
期刊：
影响因子：
4.4
通讯作者：
Russell, Steven
中科院分区：
文献类型：
--
作者：
Baker, Dean A;Meadows, Lisa A;Wang, Jing;Dow, Julian At;Russell, Steven
模式生物的野生型实验室菌株通常被隔离多年，遗传漂变和选择对突变变异的作用导致谱系随时间而分化。建立此类菌株的自然群体显示，性别特异性相互作用特别驱动序列水平和转录水平变异的许多方面。在这里，我们的目标是确定基因，显示黑腹果蝇的实验室菌株之间的转录变异，并探索性别偏见的相互作用的证据，这种变异性。研究的实验室基因型之间的转录变异发生在男性比女性更频繁。定性差异也很明显，表明特定功能类别内的基因不成比例地显示基因表达的变化。我们的分析表明，具有生殖功能的基因在两性的基因型之间最常见的是不同的，但是很大一部分女性变异也可以归因于卵巢中没有表达的基因。目前的研究清楚地表明，果蝇的常见实验室菌株之间的转录变异可以显着不同，由于性别二型性。这种变化反映了性别特异性的挑战与不同的生理权衡，形态和调节途径内运作的男性和女性。
Wild-type laboratory strains of model organisms are typically kept in isolation for many years, with the action of genetic drift and selection on mutational variation causing lineages to diverge with time. Natural populations from which such strains are established, show that gender-specific interactions in particular drive many aspects of sequence level and transcriptional level variation. Here, our goal was to identify genes that display transcriptional variation between laboratory strains of Drosophila melanogaster, and to explore evidence of gender-biased interactions underlying that variability. Transcriptional variation among the laboratory genotypes studied occurs more frequently in males than in females. Qualitative differences are also apparent to suggest that genes within particular functional classes disproportionately display variation in gene expression. Our analysis indicates that genes with reproductive functions are most often divergent between genotypes in both sexes, however a large proportion of female variation can also be attributed to genes without expression in the ovaries. The present study clearly shows that transcriptional variation between common laboratory strains of Drosophila can differ dramatically due to sexual dimorphism. Much of this variation reflects sex-specific challenges associated with divergent physiological trade-offs, morphology and regulatory pathways operating within males and females.