Serum Brain-Derived Neurotrophic Factor and Myostatin Levels Are Associated With Skeletal Muscle Mass in Kidney Transplant Recipients
Serum Brain-Derived Neurotrophic Factor and Myostatin Levels Are Associated With Skeletal Muscle Mass in Kidney Transplant Recipients
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DOI：
10.1016/j.transproceed.2021.04.021
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发表时间：
2021-08-19
影响因子：
0.9
通讯作者：
Matsuda, Tadashi
中科院分区：
文献类型：
--
作者：
Koito, Yuya;Yanishi, Masaaki;Matsuda, Tadashi
背景。肌肉减少症，或肌肉量减少，可能是肾移植受者的一个重要并发症。最近有报道称，骨骼肌分泌多种肌肉因子，如脑源性神经营养因子（BDNF）和肌肉生长抑制素，以调节其质量、功能或两者兼而有之。本研究的目的是分析肾移植受者的肌肉生长因子（BDNF和肌肉生长抑制素）和骨骼肌质量之间的相互关系。方法。研究人群包括40名在关西医科大学医院接受肾移植的患者。20例患者经双能x线骨骼肌质量指数（SMI）测量值较低，分为低和正常两组。结果。低SMI组平均血清BDNF水平为15.7 ng/mL，正常组平均血清BDNF水平为17.8 ng/mL （P = 0.013）。低SMI组平均血清肌生成抑制素水平为362 pg/mL，正常组为267 pg/mL （P = 0.024）。代谢当量与血清BDNF水平呈显著正相关（r = 0.817, P < .001），代谢当量与血清肌生长抑制素水平呈显著负相关（r = -0.541, P < .001）。受试者工作特征分析显示，血清BDNF和曲线下面积水平为0.712，血清肌生长抑制素曲线下面积水平为0.690。血清BDNF和肌肉生长抑制素水平无显著差异。结论。这些结果表明BDNF和肌肉生长抑制素是肾移植受者肌肉量减少的潜在生物标志物。
Background. Sarcopenia, or reduced muscle mass, can be an important complication in kidney transplant recipients. The skeletal muscles were recently reported to secrete various myokines, such as brain-derived neurotrophic factor (BDNF) and myostatin, to regulate their mass, function, or both. The aim of the present study was to analyze the interrelationship between myokines (BDNF and myostatin) and skeletal muscle mass in kidney transplant recipients. Methods. The study population comprised 40 patients who underwent kidney transplantation at Kansai Medical University Hospital. Twenty patients had low skeletal muscle mass index (SMI) values, as measured on dual-energy x-ray absorptiometry, and were categorized into 2 groups (low SMI and normal). Results. Mean serum BDNF levels were 15.7 ng/mL in the low SMI group and 17.8 ng/mL in the normal group (P = .013). Mean serum myostatin levels were 362 pg/mL in the low SMI and 267 pg/mL in the normal group (P = .024). There was a significant positive correlation among metabolic equivalents and serum BDNF levels (r = 0.817; P < .001) and a significant negative correlation among metabolic equivalents and serum myostatin levels (r = -0.541; P < .001). Receiver operating characteristic analysis showed that serum BDNF and level of area under curve was 0.712, and serum myostatin level of area under the curve was 0.690. Serum BDNF and myostatin levels showed no significant difference. Conclusion. These results suggest that BDNF and myostatin are potential biomarkers of reduced muscle mass in kidney transplant recipients.