Maternal and fetal serum lipid and lipoprotein concentrations and compositions in type 1 diabetic pregnancy: Relationship with maternal glycemic control
Maternal and fetal serum lipid and lipoprotein concentrations and compositions in type 1 diabetic pregnancy: Relationship with maternal glycemic control
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DOI：
10.1067/mlc.2000.111004
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发表时间：
2000-12-01
期刊：
影响因子：
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通讯作者：
Belleville, J
中科院分区：
文献类型：
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作者：
Merzouk, H;Madani, S;Belleville, J
本研究的目的是确定孕妇和胎儿的脂蛋白谱在1型糖尿病孕妇不同的血糖控制。通过Isolab柱层析法测定的血红蛋白A（1c）（HbA（1c））浓度和巨体细胞计数法测定的血红蛋白A（1c）浓度，研究了控制不佳或控制良好的1型糖尿病母亲的血脂、载脂蛋白和脂蛋白脂质浓度。（体重= 4650 +/- 90 g）或适合胎龄的新生儿（体重= 3616 +/- 68 g），并将这些水平与健康母亲及其对照新生儿（体重= 3290 +/- 45 g）的水平进行比较。在糖尿病控制良好的母亲及其婴儿中，血脂、载脂蛋白和脂蛋白脂质浓度与对照母亲及其对照新生儿中的血脂、载脂蛋白和脂蛋白脂质浓度相当。与对照值相比，糖尿病控制不佳的母亲血清甘油三酯和载脂蛋白B-100（apo B-100）水平较高，但apo A-I和HDL 3胆固醇和磷脂水平较低。巨大儿的血脂、载脂蛋白、脂蛋白水平均高于对照组。在糖尿病控制不佳组中，妊娠晚期母亲HbA（1c）和甘油三酯水平是胎儿血脂和脂蛋白的重要预测因子。总之，在良好的代谢控制下，1型糖尿病不会影响母体和胎儿的脂质水平。然而，当代谢控制不良时，1型糖尿病与母体和胎儿脂蛋白异常相关。
The aim of this study was to determine maternal and fetal lipoprotein profiles in type 1 diabetic pregnancies differing in glycemic control. Serum lipid, apolipoprotein, and lipoprotein lipid concentrations were investigated in mothers with poorly controlled or well-controlled type 1 diabetes as reflected by hemoglobin A(1c)(HbA(1c)) concentrations performed by isolab column chromatography and in their macrosomic (body wt = 4650 +/- 90 g) or appropriate-for-gestational-age newborns (body wt = 3616 +/- 68 g), and these levels were compared with those in healthy mothers and in their control newborns (body wt = 3290 +/- 45 g). In mothers with well-controlled diabetes and in their infants, serum lipid, apolipoprotein, and lipoprotein lipid concentrations were comparable to those in control mothers and in their control newborns. Mothers with poorly controlled diabetes presented higher serum triglyceride and apoprotein B-100 (apo B-100) levels but lower apo A-I and HDL3 cholesterol and phospholipid levels as compared with control values. In their macrosomic newborns, all serum lipid, apolipoprotein, and lipoprotein lipid levels were higher than those in control newborns. Maternal HbA(1c) and triglyceride levels in late gestation were significant predictors of fetal lipids and lipoproteins in the poorly controlled diabetes group. In conclusion, when under good metabolic control, type 1 diabetes did not affect maternal and fetal lipid levels. However, when under poor metabolic control, type 1 diabetes is associated with maternal and fetal lipoprotein abnormalities.