Activation of POMC neurons during general arousal but not sexual behavior in male rats
Activation of POMC neurons during general arousal but not sexual behavior in male rats
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DOI：
10.1037/0735-7044.121.5.1012
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发表时间：
2007-10-01
影响因子：
1.9
通讯作者：
Coolen, Lique M.
中科院分区：
文献类型：
--
作者：
Davis, Brooke A.;Fitzgerald, Maureen E.;Coolen, Lique M.
外源性阿片肽影响雄性大鼠性行为，提示交配过程中释放内源性阿片肽。支持这一假说的作者最近表明，交配诱导了坚果阿片受体的激活。然而。目前尚不清楚在交配过程中，是哪种配体(S)作用于这些受体。目前的一系列实验验证了这一假设，即产生β内啡肽的神经元。也就是说，前阿片促黑质皮质素(POMC)神经元在性行为中被激活。交配诱导的POMC神经元的激活在暗相和亮相都没有表现出来。遵循雄性大鼠性行为的不同组成部分，或遵循导致一般唤醒的对照操作。结果显示，在全身性唤醒后，下丘脑内侧基底核的POMC神经元被激活，但本身与性行为本身没有特殊的关系。此外，交配并没有激活投射到视前内侧核的POMC神经元亚群。这些结果表明，POMC神经元不太可能参与性行为过程中脑区内源性阿片类药物的作用，而可能有助于性行为表达所必需的觉醒状态的改变。
Exogenous opioids influence male rat sexual behavior, suggesting that endogenous opioid peptides are released during mating. Supporting this hypothesis, the authors recently showed that mating induced activation of nut opioid receptors. However. it is unknown which ligand(s) is acting on these receptors during mating. The Current set of experiments tested the hypothesis that beta-endorphin-producing neurons. that is, proopiornelanocortin (POMC) neurons, are activated during sexual behavior. Mating-induced activation of POMC neurons was nivestiEated during either the dark phase or the light phase. following different components of male rat sexual behavior or following control manipulations that resulted in general arousal. Results show activation of POMC neurons in the mediobasal hypothalamus following aeneral arousal but not specifically related to sexual behavior per se. In addition, mating did not activate the subpopulation of POMC neurons that project to the medial preoptic nucleus. These results suggest that it is unlikely that POMC neurons contribute to the action of endogenous opioids in the brain area during, sexual behavior but instead may contribute to the change in arousal state essential for the expression of sexual behavior.