AUTOIMMUNE LIVER-DISEASE IN PATIENTS WITH PRIMARY SJOGRENS-SYNDROME
AUTOIMMUNE LIVER-DISEASE IN PATIENTS WITH PRIMARY SJOGRENS-SYNDROME
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DOI：
10.1016/s0168-8278(94)80007-3
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发表时间：
1994-03-01
影响因子：
25.7
通讯作者：
ERIKSSON, S
中科院分区：
文献类型：
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作者：
LINDGREN, S;MANTHORPE, R;ERIKSSON, S
研究了45例原发性干燥综合征患者自身免疫性肝病的证据。29例患者肝功能检查正常，IgM正常，抗线粒体抗体和平滑肌抗体检查正常。在其余16例患者中，12例（占所有患者的27%）肝功能检查异常;其中8例患者有生化胆汁淤积。在9名患者中观察到血浆IgM升高（> 2 g/l），其中3名肝功能检查正常，而在6名患者中观察到抗线粒体抗体阳性，其中1名肝功能检查正常，在3名患者中发现平滑肌抗体。根据这些发现和经皮肝活检，诊断原发性胆汁性肝硬化的四名患者和自身免疫性慢性活动性肝炎的两个。目前的研究表明，原发性干燥综合征患者的肝功能检查异常是常见的，可能表明相关的自身免疫性肝病。这些数据进一步强调了自身免疫性疾病的系统性。(C)肝病学杂志。
Forty-five patients with primary Sjogren's syndrome were studied for evidence of autoimmune liver disease. Twenty-nine patients had normal liver function tests, normal IgM and a normal test for antimitochondrial antibodies and smooth muscle antibodies. Among the remaining 16 patients, abnormal liver function tests were found in 12 (27% of all patients); eight of these patients had biochemical cholestasis. Elevated plasma IgM (> 2 g/l) was observed in nine patients, three with normal liver function tests, while antimitochondrial antibodies were positive in six patients, one with normal liver function tests, and smooth muscle antibodies were found in three. Based on these findings and percutaneous liver biopsy, a diagnosis of primary biliary cirrhosis was established in four patients and autoimmune chronic active hepatitis in two. The present study showed that abnormal liver function tests in patients with primary Sjogren's syndrome are frequent and may indicate associated autoimmune liver disease. These data further emphasize the systemic nature of autoimmune disorders. (C) Journal of Hepatology.