Revisiting the effects of the reciprocal function between alveolar ventilation and CO2 partial pressure (PACO2) on PACO2 homeostasis at rest and in exercise.
Revisiting the effects of the reciprocal function between alveolar ventilation and CO2 partial pressure (PACO2) on PACO2 homeostasis at rest and in exercise.
复制标题
重新审视肺泡通气量和二氧化碳分压 (PACO2) 之间的倒数函数对静息和运动时 PACO2 稳态的影响。
DOI：
10.1152/japplphysiol.00058.2022
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Haouzi,Philippe
中科院分区：
文献类型：
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作者：
Haouzi,Philippe
本文讨论了肺泡通气功能（Va，每单位时间肺内动员的气体体积，有助于肺气体交换）与肺泡气体中 CO2 平均分压 (PACO2) 的“倒数 (1/x) 性质”的一些临床相关影响。这种相互作用对呼吸控制产生了根本性的限制，而呼吸控制对于休息和运动时肺泡气体的稳态和稳定性至关重要。随着低碳酸血症的发生，这种功能还会在剧烈运动期间带来重大的通气挑战。
This paper discusses some of the clinically relevant effects of the “reciprocal (1/x) nature” of the function linking alveolar ventilation (Va, the volume of gas mobilized in the lungs, per unit of time, contributing to the pulmonary gas exchanges) to the mean partial pressure of CO2 in the alveolar gas (PACO2). This reciprocal function exerts fundamental constraints on the control of respiration, which are essential for alveolar gases homeostasis and stability, at rest and in exercise. This function also imposes major ventilatory challenges during heavy exercise, as hypocapnia develops.