A population-based study of morbidity and mortality in mannose-binding lectin deficiency
A population-based study of morbidity and mortality in mannose-binding lectin deficiency
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DOI：
10.1084/jem.20040111
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发表时间：
2004-05-17
影响因子：
15.3
通讯作者：
Nordestgaard, BG
中科院分区：
文献类型：
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作者：
Dahl, M;Tybjærg, A;Nordestgaard, BG
野生型甘露糖结合凝集素（MBL）水平降低可能会增加感染、其他常见疾病和死亡的易感性。我们分别在24年、24年和8年的随访中调查了MBL缺乏与感染风险、其他常见疾病和死亡之间的关系。我们对9,245名成年丹麦人进行了MBL缺乏症等位基因B、C和D的基因分型，与正常的非携带者A等位基因相反。每万人住院率。非携带者的年数为644，而杂合子为631（对数秩：P = 0.39），缺陷纯合子为658（P = 0.53）。每万人死亡率。非携带者235年，杂合子244年（P = 0.44），缺陷纯合子274年（P = 0.12）。按住院或死亡的具体原因分层后，只有心血管疾病的住院率在缺陷纯合子与非携带者中增加（P = 0.02）。当在两个病例对照研究中重新测试时，这种关联无法得到证实。缺陷纯合子和非携带者的住院或死亡前感染或其他严重常见疾病的发生率没有差异。总之，在这项在种族同质的高加索人群中进行的大型研究中，没有证据表明MBL缺陷个体与对照组在感染性疾病或死亡率方面存在显著差异。我们的研究结果表明，MBL缺乏症是不是一个主要的危险因素的发病率或死亡的成年白人人口。
Reduced levels of wild-type mannose-binding lectin (MBL) may increase susceptibility for infection, other common diseases, and death. We investigated associations between MBL deficiency and risk of infection, other common diseases, and death during 24, 24, and 8 yr of follow-up, respectively. We genotyped 9,245 individuals from the adult Danish population for three MBL deficiency alleles, B, C, and D, as opposed to the normal noncarrier A allele. Hospitalization incidence per 10,000 person . yr was 644 in noncarriers compared with 631 in heterozygotes (log-rank: P = 0.39) and 658 in deficiency homozygotes (P = 0.53). Death incidence per 10,000 person . yr was 235 in noncarriers compared with 244 in heterozygotes (P = 0.44) and 274 in deficiency homozygotes (P = 0.12). After stratification by specific cause of hospitalization or death, only hospitalization from cardiovascular disorders was increased in deficiency homozygotes versus noncarriers (P = 0.02). When retested in two case control studies, this association could not be confirmed. Incidence of hospitalization or death front infections or other serious common disorders did not differ between deficiency homozygotes and noncarriers. In conclusion, in this large study in an ethnically homogenous Caucasian population, there was no evidence for significant differences in infectious disease or mortality in MBL-deficient individuals versus controls. Our results suggest that MBL deficiency is not a major risk factor for morbidity or death in the adult Caucasian population.