Deep-brain stimulation in the subthalamic nuclei improves balance performance in patients with Parkinson's disease, when tested without anti-parkinsonian medication
Deep-brain stimulation in the subthalamic nuclei improves balance performance in patients with Parkinson's disease, when tested without anti-parkinsonian medication
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DOI：
10.1111/j.1600-0404.2005.00394.x
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发表时间：
2005-05-01
影响因子：
3.5
通讯作者：
Rehncrona, S
中科院分区：
文献类型：
--
作者：
Nilsson, MH;Törnqvist, AL;Rehncrona, S
目的-评价在不使用抗帕金森病药物的情况下，丘脑底核（DBS）双侧脑深部电刺激（DBS）对严重帕金森病（PD）患者平衡性能的影响。材料和方法-纳入31例患者（中位年龄65岁，范围50-77）。在停药后10-12小时、术前、术后6个月和12个月进行评估。在DBS打开和关闭的情况下进行术后评价。采用贝格平衡量表（BBS）评价平衡能力。运动症状和姿势稳定性（第30项）采用统一帕金森病评定量表（UNITED Parkinson's Disease Rating Scale，CAFRS III）进行评估。结果：DBS治疗后平衡能力、姿势稳定性和运动症状明显改善（P
Objective - To evaluate the effect of bilateral deep-brain stimulation (DBS) in the subthalamic nucleus (STN) on balance performance in patients with severe Parkinson's disease (PD), when tested without anti-parkinsonian medication. Material and methods - Thirty-one patients (median age 65 years, range 50-77) were included. Assessments were made after 10-12 h withdrawal of medication, before and 6 and 12 months after surgery. Postoperative evaluations were performed with DBS on and off. Balance performance was evaluated with the Berg Balance Scale (BBS). Motor symptoms and postural stability (item 30) were assessed with the Unified Parkinson's Disease Rating Scale (UPDRS III). Results - DBS in STN improved balance performance as well as postural stability and motor symptoms significantly (P