INTRAVENOUS IMMUNOGLOBULIN IN THE TREATMENT OF SALMONELLA-TYPHIMURIUM INFECTIONS IN PRETERM NEONATES
INTRAVENOUS IMMUNOGLOBULIN IN THE TREATMENT OF SALMONELLA-TYPHIMURIUM INFECTIONS IN PRETERM NEONATES
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DOI：
10.1177/000992289403300607
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发表时间：
1994-06-01
影响因子：
1.6
通讯作者：
KAYA, R
中科院分区：
文献类型：
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作者：
GOKALP, AS;TOKSOY, HB;KAYA, R
本研究的目的是确定静脉注射免疫球蛋白 (IVIG) 对感染鼠伤寒沙门氏菌的早产儿的作用。对 47 名患有肠道或肠外鼠伤寒沙门氏菌感染的早产新生儿进行了一项随机试验。将新生儿随机分为两组：22名新生儿仅给予头孢哌酮（第1组）； 25 名新生儿接受头孢哌酮加 IVIG 治疗（第 2 组）。在进入研究后的第1、2、3和8天以500 mg/kg的剂量给予IVIG。治疗后，对两组的菌血症、并发症、死亡率、恢复时间和抗菌治疗持续时间进行评估。第 1 组中 31.4% 发生菌血症，第 2 组中 8% 发生菌血症（P
The purpose of this study was to determine the role of intravenous immunoglobulin (IVIG) administration in preterm neonates with S. typhimurium infection. A randomized trial of 47 preterm neonates with intestinal or extraintestinal S. tymphimurium infection was performed. Neonates were randomly divided into two groups: 22 neonates were only given cefoperazone (group 1); 25 neonates were given cefoperazone plus IVIG (group 2). IVIG was given at a dose of 500 mg/kg on da)is 1, 2, 3, and 8 after entry into the study. Following treatment, bacteremia, complications, mortality rate, recovery time, and duration of antimicrobial therapy were evaluated in two groups. Bacteremia was found in 31.4% in group 1 and 8% in group 2 (P