A ROLE IN B-CELL ACTIVATION FOR CD22 AND THE PROTEIN-TYROSINE-PHOSPHATASE SHP
A ROLE IN B-CELL ACTIVATION FOR CD22 AND THE PROTEIN-TYROSINE-PHOSPHATASE SHP
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DOI：
10.1126/science.7618087
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发表时间：
1995-07-14
期刊：
影响因子：
56.9
通讯作者：
FEARON, DT
中科院分区：
文献类型：
--
作者：
DOODY, GM;JUSTEMENT, LB;FEARON, DT
CD22是B细胞的膜免疫球蛋白（mlg）相关蛋白。当连接mlg时，CD22被酪氨酸磷酸化。酪氨酸磷酸化的CD22结合并激活SHP，SHP是一种已知通过mlg负调节信号传导的蛋白酪氨酸磷酸酶。连接CD22以防止其与mlg的共聚集降低mlg激活B细胞的阈值100倍。在次级淋巴器官中，CD22可以通过与T细胞上的反受体相互作用而与mlg隔离。因此，CD22是SHP的分子开关，其可以将mlg信号传导偏向于富含T细胞的解剖部位。
CD22 is a membrane immunoglobulin (mlg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mlg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mlg. Ligation of CD22 to prevent its coaggregation with mlg lowers the threshold at which mlg activates the B cell by a factor of 100. In secondary lymphoid organs, CD22 may be sequestered away from mlg through interactions with counterreceptors on T cells. Thus, CD22 is a molecular switch for SHP that may bias mlg signaling to anatomic sites rich in T cells.