Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma
Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma
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DOI：
10.1007/s11682-012-9164-5
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发表时间：
2012-06-01
影响因子：
3.2
通讯作者：
Stern, Robert A.
中科院分区：
文献类型：
--
作者：
Baugh, Christine M.;Stamm, Julie M.;Stern, Robert A.
慢性创伤性脑病（CTE）是一种神经退行性疾病，被认为至少部分是由重复性脑创伤引起的，包括震荡和亚震荡损伤。它被认为会导致执行功能障碍、记忆障碍、抑郁和自杀倾向、冷漠、冲动控制不良，最终导致痴呆。除了重复性脑外伤，CTE的风险因素仍然未知。CTE在神经病理学上以过度磷酸化的tau和TDP-43的聚集和积累为特征。最近的尸检结果表明，CTE可能会影响更广泛的人群比最初的概念，特别是接触体育运动员和那些有军事战斗史。鉴于可能受到影响的人群众多，CTE可能是公共卫生中的一个重要问题。虽然近年来公众对这种情况的认识有所提高，但仍然存在许多研究问题。到目前为止，CTE只能在死后诊断。目前的研究工作集中在创建临床诊断标准，寻找CTE的客观生物标志物，并了解导致疾病的其他风险因素和潜在机制。这篇评论审查了迄今为止的研究，并提出了未来值得探索的方向。
Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease thought to be caused, at least in part, by repetitive brain trauma, including concussive and subconcussive injuries. It is thought to result in executive dysfunction, memory impairment, depression and suicidality, apathy, poor impulse control, and eventually dementia. Beyond repetitive brain trauma, the risk factors for CTE remain unknown. CTE is neuropathologically characterized by aggregation and accumulation of hyperphosphorylated tau and TDP-43. Recent postmortem findings indicate that CTE may affect a broader population than was initially conceptualized, particularly contact sport athletes and those with a history of military combat. Given the large population that could potentially be affected, CTE may represent an important issue in public health. Although there has been greater public awareness brought to the condition in recent years, there are still many research questions that remain. Thus far, CTE can only be diagnosed post-mortem. Current research efforts are focused on the creation of clinical diagnostic criteria, finding objective biomarkers for CTE, and understanding the additional risk factors and underlying mechanism that causes the disease. This review examines research to date and suggests future directions worthy of exploration.