Upregulation of NETO2 gene in colorectal cancer.
Upregulation of NETO2 gene in colorectal cancer.
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DOI：
10.1186/s12863-017-0581-8
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发表时间：
2017-12-28
期刊：
影响因子：
2.9
通讯作者：
Kudryavtseva AV
中科院分区：
文献类型：
--
作者：
Fedorova MS;Snezhkina AV;Pudova EA;Abramov IS;Lipatova AV;Kharitonov SL;Sadritdinova AF;Nyushko KM;Klimina KM;Belyakov MM;Slavnova EN;Melnikova NV;Chernichenko MA;Sidorov DV;Kiseleva MV;Kaprin AD;Alekseev BY;Dmitriev AA;Kudryavtseva AV
Neuropilin 和 tolloid-like 2 (NETO2) 是一种单次跨膜蛋白，已被证明主要与神经元特异性过程有关。在几种癌症类型中也检测到 NETO2 基因的上调。在结直肠癌（CRC）中，它与肿瘤进展、侵袭和转移相关，并且似乎参与上皮-间质转化（EMT）。然而，人们对 NETO2 的作用机制仍知之甚少。我们发现结直肠癌中 NETO2 基因的表达显着增加，八个 EMT 相关基因的失调。其中 4 个表达上调（TWIST1、SNAIL1、LEF1 和 FOXA2）；其他基因（FOXA1、BMP2、BMP5 和 SMAD7）的 mRNA 水平降低。 NETO2基因的表达与EMT过程相关基因的表达呈弱相关。我们发现结直肠癌中 NETO2 显着上调，但 NETO2 和 EMT 相关基因的表达之间没有显着相关性。因此，NETO2可能参与CRC进展，但与EMT没有直接关系。
Neuropilin and tolloid-like 2 (NETO2) is a single-pass transmembrane protein that has been shown primarily implicated in neuron-specific processes. Upregulation of NETO2 gene was also detected in several cancer types. In colorectal cancer (CRC), it was associated with tumor progression, invasion, and metastasis, and seems to be involved in epithelial-mesenchymal transition (EMT). However, the mechanism of NETO2 action is still poorly understood. We have revealed significant increase in the expression of NETO2 gene and deregulation of eight EMT-related genes in CRC. Four of them were upregulated (TWIST1, SNAIL1, LEF1, and FOXA2); the mRNA levels of other genes (FOXA1, BMP2, BMP5, and SMAD7) were decreased. Expression of NETO2 gene was weakly correlated with that of genes involved in the EMT process. We found considerable NETO2 upregulation, but no significant correlation between the expression of NETO2 and EMT-related genes in CRC. Thus, NETO2 may be involved in CRC progression, but is not directly associated with EMT.
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影响因子：
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