Development of a map of chromosome 11p.
Development of a map of chromosome 11p.
复制标题
绘制 11p 号染色体图谱。
DOI：
10.1002/gepi.1370030724
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Kidd,KK
中科院分区：
文献类型：
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作者：
Kramer,PL;Farrer,LA;Pakstis,AJ;Kidd,KK
我们提出顺序HRAS 1-（INS，IGF 2）-D11 S12-HBBC-PTH-CALC 1-CAT。INS和IGF 2被认为是一个单一的基因座，因为没有检测到交叉，有证据表明它们彼此在15 kb内（Grzeschik和Kazazian，HGM 8）。3点和4点LINKMAP分析中不同假设的检验（即，允许哪些基因座发生变化）得出了HRAS 1-INS、D11 S12-HBBC和INS-HBBC重组的最大似然估计值范围。HBBC-PTH、PTH-CALC 1和CALC 1-CAT的值范围是对研讨会数据和来自研讨会未包括的两个大型参考家系的数据进行2点分析的结果。
We propose the order HRAS1-(INS, IGF2)-D11S12-HBBC-PTH-CALC1-CAT. INS and IGF2 are considered a single locus since no crossovers were detected and evidence indicates that they are within 15 kb of each other (Grzeschik and Kazazian, HGM8). Tests of different hypotheses (ie, which loci were allowed to vary) in the 3-and 4-point LINKMAP analyses gave rise to the range of maximum likelihood estimates of recombination for HRAS1-INS, D11S12-HBBC and INS-HBBC. The ranges of values for HBBC-PTH, PTH-CALC1, and CALC1-CAT are the result of 2-point analyses of Workshop data and data from two large reference pedigrees not included in the Workshop.