Maxi-K(Ca), a Unique Member of the Voltage-Gated K Channel Superfamily.

Maxi-K(Ca), a Unique Member of the Voltage-Gated K Channel Superfamily.
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DOI：
10.1152/physiologyonline.1998.13.3.112
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发表时间：
1998-06
期刊：
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
影响因子：
--
通讯作者：
L. Toro;M. Wallner;P. Meera;Yoshitomo Tanaka
L. Toro;M. Wallner;P. Meera;Yoshitomo Tanaka
中科院分区：
其他
文献类型：
--
作者：
L. Toro;M. Wallner;P. Meera;Yoshitomo Tanaka

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大电导、电压和Ca（2+）敏感性K（+）（maxi-K（Ca））通道调节神经元和平滑肌的兴奋性。它们的成孔α亚基显示出与电压门控通道的相似性，并且确实可以在实际缺乏Ca（2+）的情况下打开。NH（2）末端是独特的，具有参与β亚基调节的第七个跨膜区段。长的COOH末端暗示在Ca（2+）调节中。
Large-conductance, voltage-, and Ca(2+)-sensitive K(+) (maxi-K(Ca)) channels regulate neuronal and smooth muscle excitability. Their pore-forming alpha-subunit shows similarities with voltage-gated channels and indeed can open in the practical absence of Ca(2+). The NH(2) terminus is unique, with a seventh transmembrane segment involved in beta-subunit modulation. The long COOH terminus is implied in Ca(2+) modulation.