Transcatheter Mitral Valve Replacement Insights From Early Clinical Experience and Future Challenges
Transcatheter Mitral Valve Replacement Insights From Early Clinical Experience and Future Challenges
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DOI：
10.1016/j.jacc.2017.02.045
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发表时间：
2017-05-02
影响因子：
24
通讯作者：
Rodes-Cabau, Josep
中科院分区：
文献类型：
--
作者：
Regueiro, Ander;Granada, Juan F.;Rodes-Cabau, Josep
Transcatheter mitral valve repair, particularly edge-to-edge leaflet repair, is a well-established alternative for patients with severe primary mitral regurgitation (MR) considered at high or prohibitive surgical risk. More recently, transcatheter mitral valve replacement (TMVR) has emerged as a potential therapeutic option for the treatment of severe MR. TMVR may offer some advantages over transcatheter repair by providing a more complete and reproducible MR reduction. Several devices are under preclinical and clinical evaluation, and the early experience with more than 100 patients has demonstrated the feasibility of TMVR. In this review, we describe the TMVR systems currently in development and the results obtained from early clinical experiences. We also discuss the main challenges in and future perspectives on this emerging field. Future studies with a much larger number of patients are needed to provide consistent safety and efficacy data on each of the TMVR systems. (C) 2017 by the American College of Cardiology Foundation.
