RISK-FACTORS FOR PROLIFERATIVE SICKLE RETINOPATHY
RISK-FACTORS FOR PROLIFERATIVE SICKLE RETINOPATHY
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DOI：
10.1136/bjo.74.3.172
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发表时间：
1990-03-01
影响因子：
4.1
通讯作者：
SERJEANT, GR
中科院分区：
文献类型：
--
作者：
FOX, PD;DUNN, DT;SERJEANT, GR
对786名纯合子镰状细胞（SS）病患者和533名镰状细胞血红蛋白C（SC）病患者进行了增殖性镰状视网膜病变（PSR）的患病率、发病率及相关危险因素的调查。PSR在SC病中更为常见，其中男性明显占优势，且在两种基因型中均随年龄增长而增加。在SC病中，男性在15 - 24岁之间、女性在20 - 39岁之间发生PSR的风险最高，而在SS病中，男女在25 - 39岁之间发生PSR的风险最高。PSR往往是双侧的，尤其是在SC病中。在SC病的兄弟姐妹中没有PSR家族聚集的证据，且由于SS病的兄弟姐妹数量不足，无法进行聚集性检测。与SS病中PSR相关的血液学危险因素是男性的高血红蛋白以及男女的低胎儿血红蛋白，而在SC病中，女性的平均细胞体积高以及胎儿血红蛋白低。
The prevalence, incidence, and risk factors associated with proliferative sickle retinopathy (PSR) were investigated in 786 patients with homozygous sickle cell (SS) disease and 533 patients with sickle cell haemoglobin C (SC) disease. PSR was more common in SC disease, in which there was a significant predominance of males, and it increased with age in both genotypes. In SC disease the risk of developing PSR was highest between 15 and 24 years in males, between 20 and 39 years in females, and in SS disease between 25 and 39 years in both sexes. PSR tended to be bilateral, especially in SC disease. There was no evidence of familial clustering of PSR in SC siblings, and insufficient numbers of SS siblings were available to test for clustering. Haematological risk factors associated with PSR in SS disease were a high haemoglobin in males and a low fetal haemoglobin in both sexes and in SC disease, a high mean cell volume, and a low fetal haemoglobin in females.