DETAILED COMPARISON OF BASAL AND FOOD-STIMULATED GASTRIC-ACID SECRETION RATES AND SERUM GASTRIN-CONCENTRATIONS IN DUODENAL-ULCER PATIENTS AND NORMAL SUBJECTS
DETAILED COMPARISON OF BASAL AND FOOD-STIMULATED GASTRIC-ACID SECRETION RATES AND SERUM GASTRIN-CONCENTRATIONS IN DUODENAL-ULCER PATIENTS AND NORMAL SUBJECTS
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DOI：
10.1172/jci112850
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发表时间：
1987-02-01
影响因子：
15.9
通讯作者：
RICHARDSON, CT
中科院分区：
文献类型：
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作者：
BLAIR, AJ;FELDMAN, M;RICHARDSON, CT
我们测量了一大群十二指肠溃疡患者和正常受试者的基础和峰值酸排出量、食物刺激的酸分泌以及基础和食物刺激的血清胃泌素浓度。溃疡患者的基础酸排出量和峰值酸排出量显着较高。相比之下，当食物注入胃中以及当假喂养与膳食输注相结合以模拟正常饮食时，各组的酸分泌相似。溃疡患者的膳食刺激酸分泌较低（P 小于 0.002），以酸输出峰值的百分比表示，以校正分泌能力的差异。溃疡患者的基础血清胃泌素浓度较高，这可能导致基础酸排出量较高。然而，各组食物后血清胃泌素的增加相似。十二指肠溃疡患者整体基础酸分泌量和最大酸分泌量增加，但进食后酸分泌量和胃泌素释放量正常。
We measured basal and peak acid outputs, food-stimulated acid secretion, and basal and food-stimulated serum gastrin concentrations in a large group of duodenal ulcer patients and normal subjects. Basal and peak acid outputs were significantly higher in ulcer patients. In contrast, acid secretion was similar in the groups when food was infused into the stomach and when sham feeding was combined with meal infusion to simulate normal eating. Meal-stimulated acid secretion, expressed as a percentage of peak acid output to correct for differences in secretory capacity, was lower in ulcer patients (P less than 0.002). Basal serum gastrin concentrations were higher in ulcer patients, which may have contributed to higher basal acid output. However, increases in serum gastrin after food were similar in the groups. Duodenal ulcer patients, as a group, have increased basal and maximal acid secretion, but the amount of acid secreted and gastrin released after eating is normal.