Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.
Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.
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DOI：
10.1021/acs.jnatprod.5b00540
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发表时间：
2015-11-01
影响因子：
5.1
通讯作者：
Trujillo, Martha E.
中科院分区：
文献类型：
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作者：
Igarashi, Yasuhiro;Yamamoto, Kazuki;Trujillo, Martha E.
与链霉菌等丝状放线菌相比，非丝状放线菌作为次生代谢物的研究较少。从我们收集的从砂岩中分离的非丝状放线菌中，发现一种节杆菌菌株产生一种新的环状肽节酰胺(1)和已知的化合物turnagainolide a(2)。这些化合物在亚微摩尔到微摩尔范围内抑制金黄色葡萄球菌的群体感应信号。
Nonfilamentous actinobacteria have been less studied as secondary metabolite producers than their filamentous counterparts such as Streptomyces. From our collection of nonfilamentous actinobacteria isolated from sandstone, an Arthrobacter strain was found to produce a new cyclic peptide arthroamide (1) together with the known compound turnagainolide A (2). These compounds inhibited the quorum sensing signaling of Staphylococcus aureus in the submicromolar to micromolar range.